Multi-enzyme cascade synthesis of the most odorous stereoisomers of the commercial odorant Muguesia®
Multi-enzyme cascade synthesis of the most odorous stereoisomers of the commercial odorant Muguesia®
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DOI：
10.1016/j.molcatb.2014.10.006
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发表时间：
2015-04-01
影响因子：
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通讯作者：
Santangelo, Sara
中科院分区：
文献类型：
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作者：
Brenna, Elisabetta;Crotti, Michele;Santangelo, Sara
手性商业香精木桂叶(R)的最具气味的立体异构体是通过非常有效的线性生物催化级联反应制备的，其中一个合适的不饱和酮在酶还原酶和醇脱氢酶两种酶的连续作用下，与辅因子再生系统一起加入到同一个反应容器中。在1,2相对位置上的两个立体中心因此在高立体化学控制下通过两步一锅酶程序产生。(C) 2014 Elsevier B.V.版权所有
The most odorous stereoisomers of the chiral commercial fragrance Muguesie (R) are prepared by a very effective linear biocatalysed cascade reaction, in which a suitable unsaturated ketone is submitted to the sequential action of two enzymes, an ene-reductase and an alcohol dehydrogenase, which are added together to the same reaction vessel with the cofactor regeneration system. Two stereogenic centres in 1,2 relative position are thus created under high stereochemical control by a two-step one-pot enzymatic procedure. (C) 2014 Elsevier B.V. All rights reserved.