HISTOLOGIC CHANGES IN NORMAL AGING AORTA - IMPLICATIONS FOR DISSECTING AORTIC-ANEURYSM
HISTOLOGIC CHANGES IN NORMAL AGING AORTA - IMPLICATIONS FOR DISSECTING AORTIC-ANEURYSM
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DOI：
10.1016/s0002-9149(77)80004-0
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发表时间：
1977-01-01
影响因子：
2.8
通讯作者：
BECKER, AE
中科院分区：
文献类型：
--
作者：
SCHLATMANN, TJM;BECKER, AE
研究了100条正常主动脉中膜在不同年龄的组织学变化。这些变化包括：(1)囊性内侧坏死，定义为粘液样物质淤积；(2)弹性蛋白断裂，以弹性蛋白片层断裂为特征；(3)纤维化，定义为以平滑肌细胞为代价的胶原蛋白增加；(4)中坏死，定义为细胞核明显丢失的区域。这些变化与年龄有显著的相关性，可能代表了组织学上确定的主动脉的正常衰老过程。这些改变在介质内的发生和位置上有密切的关系，表明一种由血流动力学事件引起的损伤和修复现象。这些在正常老化主动脉中的发现表明，所观察到的组织学变化都不能被认为是导致夹层动脉瘤发展的特定结构改变。
The histologic changes that occur in the media of the normal aorta at various ages were studied in 100 normal aortas. These changes encompassed (1) cystic medial necrosis, defined as pooling of mucoid material; (2) elastin fragmentation, characterized by disruption of elastin lamellae; (3) fibrosis, defined as an increase in collagen at the expense of smooth muscle cells; and (4) medionecrosis, defined as areas with apparent loss of nuclei. The changes showed a striking correlation with age and may represent the normal aging process for the aorta as determined histologically. The alterations showed a close relation in onset and location within the media, suggesting a phenomenon of injury and repair caused by hemodynamic events. These findings in the normal aging aorta reveal that none of the histologic changes observed can be regarded as the specific structural alteration responsible for the development of dissecting aneurysm.