A Case-Control Study of Sudden Unexplained Nocturnal Death Syndrome in the Southern Chinese Han Population
A Case-Control Study of Sudden Unexplained Nocturnal Death Syndrome in the Southern Chinese Han Population
复制标题
DOI：
10.1097/paf.0000000000000135
复制
发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Jin-xiang Zheng;Erwen Huang;Shuangbo Tang;Qiuping Wu;Lei Huang;Dongchuan Zhang;L. Quan;Chao Liu;Jianding Cheng
中科院分区：
文献类型：
--
作者：
Jin-xiang Zheng;Erwen Huang;Shuangbo Tang;Qiuping Wu;Lei Huang;Dongchuan Zhang;L. Quan;Chao Liu;Jianding Cheng
AbstractTo研究的流行病学特点原因不明的夜间猝死综合症(SUNDS)在中国南方汉族人口在2007年到2013年,我们收集了879 SUNDS受害者从东莞和深圳龙岗区城市作为病例组然后选择879例全因死亡病例,采用1:1配对方法,对照组的我和收集8142例全因死亡病例从深圳宝安地区对照组二世,同时进行。对收集到的病例信息进行统计分析。东莞市和龙岗区的sds年发病率分别为1.02和2.23 / 10万人/年。男性和女性受害者人数差异显著，比例为13.92:1，而两性之间的发病率差异显著（2 = 78.734,P 0.05）。3 - 6月SUNDS的月发病率较高，而SUNDS患者与全因死亡人群的月分布差异有统计学意义（2 = 9.869,P < 0.05），比值比为1.42（95%可信区间为1.14 ~ 1.76）。虽然大多数的猝死发生在午夜的睡眠中，但它们大多是在早上7点到9点被发现的，一旦囚犯或配偶在早上醒来。97.74%的受害者为蓝领工人，劳动强度高，教育程度低。本研究证实了华南地区sds流行病学特征的稳定性，提示该致命疾病的危险因素仍然存在。迫切需要有效的早期识别策略，如分子诊断。
AbstractTo study the epidemiological characteristics of sudden unexplained nocturnal death syndrome (SUNDS) in the southern Chinese Han population during 2007 to 2013, we gathered 879 SUNDS victims from Dongguan City and in the Longgang District in Shenzhen City as the case group then selected 879 all-cause death cases, adopting a 1:1 pair method, as the control group I and collected 8142 all-cause death cases from the Bao’an District in Shenzhen City as the control group II, simultaneously. Case information collected was statistically analyzed. The annual incidence of SUNDS is 1.02 and 2.23 per 100,000 person-years for Dongguan City and in the Longgang District, respectively. The number of male and female victims is drastically different, with a ratio of 13.92:1, whereas the incidence between the 2 sexes is significantly different (2 = 78.734, P 0.05). The monthly incidence of SUNDS is relatively higher from March to June, whereas the difference of monthly distribution between SUNDS victims and all-cause death population is significant (2 = 9.869, P < 0.05), with an odds ratio value of 1.42 (95% confidence interval, 1.14–1.76). Although the majority of SUNDS occurred during midnight sleep, they were mostly discovered from 7 to 9 am once the inmates or spouses woke in the morning. A total of 97.74% of the SUNDS victims were blue-collar factory workers with a high-intensity labor and poor education background. This investigation confirmed the stability of epidemiological characteristics of SUNDS in South China and implicated that risk factors of this fatal disease still exist. The efficient strategy of early identification such as molecular diagnosis for SUNDS is extremely urgently required.