Possible therapeutic targets for SARS-CoV-2 infection and COVID-19.
Possible therapeutic targets for SARS-CoV-2 infection and COVID-19.
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SARS-CoV-2感染和COVID-19的可能治疗靶点。
DOI：
10.46439/allergy.2.028
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Geiger JD
中科院分区：
文献类型：
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作者：
Khan N;Kumar N;Geiger JD
SARS-CoV-2感染导致COVID-19，已成为全球卫生紧急情况。SARS-CoV-2通过与ACE 2受体结合感染细胞，并在其从内溶酶体逃逸后进入细胞质。一旦在细胞质中，病毒复制并最终导致各种病理状况，包括由促炎细胞因子风暴引起的急性呼吸窘迫综合征（ARDS）。因此，内溶酶体和细胞因子风暴是抑制SARS-CoV-2感染和COVID-19的重要治疗靶点。在这里，我们讨论了SARS-CoV-2感染的治疗靶点和可能有助于抑制SARS-CoV-2感染和病理状态COVID-19的可用药物。COVID-19大流行的紧迫性阻碍了新药的开发，而对药物再利用的日益关注可能是找到有效药物的最快方法。
SARS-CoV-2 infection causes COVID-19, which has emerged as a health emergency worldwide. SARS-CoV-2 infects cells by binding to ACE2 receptors and enters into the cytoplasm following its escape from endolysosomes. Once in the cytoplasm, the virus replicates and eventually causes various pathological conditions including acute respiratory distress syndrome (ARDS) that is caused by pro-inflammatory cytokine storms. Thus, endolysosomes and cytokine storms are important therapeutic targets to suppress SARS-CoV-2 infection and COVID-19. Here, we discuss therapeutic targets of SARS-CoV-2 infection and available drugs that could be helpful in the suppression of the SARS-CoV-2 infection and pathological condition COVID-19. The urgency of the COVID-19 pandemic precludes the development of new drugs and increased focus on drug repurposing might provide the quickest way to finding effective medicines.