NO STANDARD TREATMENT IS AVAILABLE FOR ADVANCED PANCREATIC-CANCER
NO STANDARD TREATMENT IS AVAILABLE FOR ADVANCED PANCREATIC-CANCER
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DOI：
10.1016/0959-8049(94)00445-5
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发表时间：
1995-01-01
影响因子：
8.4
通讯作者：
ROSSO, R
中科院分区：
文献类型：
--
作者：
LIONETTO, R;PUGLIESE, V;ROSSO, R
对1980年至1993年发表的晚期和局部不可切除的外分泌胰腺癌治疗的所有随机试验进行了严格审查，以确定最有效的治疗策略，作为此类患者随机试验的对照组。识别所有已发表的胰腺癌患者随机试验，并通过已发表的方法学指南总结治疗结果。确定了27份报告，包括21份关于激素或化疗的报告和6份关于放疗/化疗的报告。在试验中使用了非常不同的治疗方案，没有检验假设的基本原理序列。此外，一些方法上的缺陷破坏了这些研究的内部和外部有效性。因此，不能结合1990年至1993年发表的胰腺癌随机对照试验的结果进行荟萃分析;目前晚期胰腺癌患者没有标准治疗方法;未来的研究应筛选新药或新的组合; MT未治疗的对照组应包括在未来的比较研究中，直到证明在更好的生活质量或改善的生存率方面的真实的优势。
All randomised trials, published from 1980 to 1993, of treatments in advanced and locally unresectable exocrine pancreatic carcinoma were critically reviewed to identify the most effective therapeutic strategy for use as a control arm in randomised trials for such patients. All the published randomised trials on patients with pancreatic cancer were identified, and the treatment results summarised by means of published methodological guidelines. Twenty-seven reports, including 21 on hormonal or chemotherapy and six on radio/chemotherapy were identified. Very different treatment programmes were used in the trials, without a rationale sequence for testing hypotheses. Furthermore, several methodological drawbacks undermined both the internal and the external validity of-these studies. Therefore, no meta-analysis can be conducted, combining the results of the randomised controlled trials in pancreatic cancer published from 1990 to 1993; no standard treatment is currently available for patients with advanced pancreatic cancer; future studies should screen new drugs or new combinations; and mt untreated control group should be included in future comparative studies until real advantages in terms of better quality of life or improved survival are demonstrated.