Prevalence of asymptomatic carotid artery stenosis in the general population: an individual participant data meta-analysis.
Prevalence of asymptomatic carotid artery stenosis in the general population: an individual participant data meta-analysis.
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DOI：
10.1161/strokeaha.110.581058
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发表时间：
2010-06
期刊：
影响因子：
8.3
通讯作者：
Bots ML
中科院分区：
文献类型：
--
作者：
de Weerd M;Greving JP;Hedblad B;Lorenz MW;Mathiesen EB;O'Leary DH;Rosvall M;Sitzer M;Buskens E;Bots ML
在关于筛查成本效益的讨论中，对严重无症状性颈动脉狭窄(ACAS)的准确估计至关重要。因此，我们使用汇集的队列数据，根据年龄和性别评估了中、重度ACAS的患病率。我们对四项以人群为基础的研究(MDCS、TROMSø、CAPS和CHS)进行了个人参与者数据荟萃分析(23,706名参与者)。关注的结果是无症状的中度颈动脉狭窄(≥50%)和重度颈动脉狭窄(≥70%)。50岁以下男性的中度ACAS患病率为0.5%(95%CI，0.3%至1.1%)，80岁及以上男性为5.7%(4.5%至7.1%)。对于女性，这一患病率从0.3(0.1%至0.6%)增加到4.5%(2.8%至6.8%)。50岁以下男性严重急性冠脉综合征的患病率为0.1%(0.0%至0.4%)，80岁及以上男性为1.7%(0.8%至3.4%)。对于妇女来说，这一患病率从零(0.0%到0.2%)增加到0.9%(0.4%到2.4%)。严重急性冠脉综合征在一般人群中的患病率从0到1.6%不等，这对讨论筛查的成本效益是有用的信息。
In the discussion on the cost-effectiveness of screening precise estimates of severe asymptomatic carotid stenosis (ACAS) are vital. Accordingly, we assessed the prevalence of moderate and severe ACAS by age and sex using pooled cohort data. We performed an individual participant data meta-analysis (23,706 participants) of four population-based studies (MDCS, Tromsø, CAPS and CHS). Outcomes of interest were asymptomatic moderate (≥50%) and severe carotid stenosis (≥70%). Prevalence of moderate ACAS ranged from 0.5% (95% CI, 0.3% to 1.1%) in men aged below 50 years to 5.7% (4.5% to 7.1%) in men aged 80 years and above. For women this prevalence increased from 0.3 (0.1% to 0.6%) to 4.5% (2.8% to 6.8%). Prevalence of severe ACAS ranged from 0.1% (0.0% to 0.4%) in men aged below 50 years to 1.7% (0.8% to 3.4%) in men aged 80 and above. For women this prevalence increased from zero (0.0% to 0.2%) to 0.9% (0.4% to 2.4%). Prevalence of severe ACAS in the general population ranges from zero to 1.6% which is useful information in the discussion on the cost-effectiveness of screening.