Enlarged perivascular spaces and cognitive impairment after stroke and transient ischemic attack
Enlarged perivascular spaces and cognitive impairment after stroke and transient ischemic attack
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DOI：
10.1177/1747493016666091
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发表时间：
2018-01-01
影响因子：
6.7
通讯作者：
Inzitari, Domenico
中科院分区：
文献类型：
--
作者：
Arba, Francesco;Quinn, Terence J.;Inzitari, Domenico
背景以往的研究表明，血管周围间隙增大是脑血管疾病的神经影像学标志。然而，尚不清楚血管周围空间扩大是否与认知障碍有关。我们旨在确定血管周围空间扩大与小血管疾病之间的横断面关系，并探讨近期脑缺血事件患者血管周围空间扩大与随后认知功能障碍之间的关系。方法从虚拟国际脑卒中试验档案中获取匿名数据。我们在指数脑卒中后对脑磁共振图像上的凹窝、白质高信号、脑萎缩和血管周围空间扩大的数量进行了评估。我们将认知障碍定义为中风后一年记录的最低精神状态考试分数为26分。我们使用线性和逻辑回归模型研究了血管周围空间增大与小血管疾病的临床和影像学标志物之间的关系，以及一年后认知障碍的临床证据。结果430例患者的平均（SD）年龄为64.7（±12.7）岁，276例（64%）为男性。在线性回归分析中，年龄(=0.24
Background Previous studies suggested that enlarged perivascular spaces are neuroimaging markers of cerebral small vessel disease. However, it is not clear whether enlarged perivascular spaces are associated with cognitive impairment. We aimed to determine the cross-sectional relationship between enlarged perivascular spaces and small vessel disease, and to investigate the relationship between enlarged perivascular spaces and subsequent cognitive impairment in patients with recent cerebral ischemic event.Methods Anonymized data were accessed from the virtual international stroke trial archive. We rated number of lacunes, white matter hyperintensities, brain atrophy, and enlarged perivascular spaces with validated scales on magnetic resonance brain images after the index stroke. We defined cognitive impairment as a mini mental state examination score of 26, recorded at one year post stroke. We examined the associations between enlarged perivascular spaces and clinical and imaging markers of small vessel disease at presentation and clinical evidence of cognitive impairment at one year using linear and logistic regression models.Results We analyzed data on 430 patients with mean (SD) age 64.7 (+/- 12.7) years, 276 (64%) males. In linear regression analysis, age (=0.24; p