Identification and characterization of neuroblasts in the subventricular zone and rostral migratory stream of the adult human brain
Identification and characterization of neuroblasts in the subventricular zone and rostral migratory stream of the adult human brain
复制标题
成人大脑室下区和吻侧迁移流中神经母细胞的鉴定和表征
DOI：
10.1038/cr.2011.83
复制
发表时间：
2011-11-01
期刊：
影响因子：
44.1
通讯作者：
Yang, Zhengang
中科院分区：
文献类型：
--
作者：
Wang, Congmin;Liu, Fang;Yang, Zhengang
在成人大脑中发现新的神经元是很有意义的，但关于在成人前脑中脑室下区(SVZ)的神经发生的持久性和头端迁移流(RMS)样通路的存在仍然存在很大的争议。在本研究中，我们描述了成年猴、胎儿和成人人脑中RMS的一般结构。我们提供的证据表明，神经母细胞持续存在于成人大脑的前腹侧SVZ和RMS。神经母细胞呈单个或成对出现，无成链；呈迁移形态，共表达未成熟神经元标记物Doublectin、多唾液酸化神经细胞黏附分子和βIII-微管蛋白。这些神经母细胞很少在前腹侧SVZ中活跃增殖，但在RMS中没有，这表明沿RMS分布的神经母细胞很可能来自腹侧SVZ。有趣的是，在成人嗅球中没有发现神经母细胞。综上所述，我们的数据表明，SVZ保持了在成人大脑中产生神经母细胞的能力。
It is of great interest to identify new neurons in the adult human brain, but the persistence of neurogenesis in the subventricular zone (SVZ) and the existence of the rostral migratory stream (RMS)-like pathway in the adult human forebrain remain highly controversial. In the present study, we have described the general configuration of the RMS in adult monkey, fetal human and adult human brains. We provide evidence that neuroblasts exist continuously in the anterior ventral SVZ and RMS of the adult human brain. The neuroblasts appear singly or in pairs without forming chains; they exhibit migratory morphologies and co-express the immature neuronal markers doublecortin, polysialylated neural cell adhesion molecule and beta III-tubulin. Few of these neuroblasts appear to be actively proliferating in the anterior ventral SVZ but none in the RMS, indicating that neuroblasts distributed along the RMS are most likely derived from the ventral SVZ. Interestingly, no neuroblasts are found in the adult human olfactory bulb. Taken together, our data suggest that the SVZ maintains the ability to produce neuroblasts in the adult human brain.