Neural stem/precursor cells for the treatment of ischemic stroke
Neural stem/precursor cells for the treatment of ischemic stroke
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DOI：
10.1016/j.jns.2007.06.012
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发表时间：
2008-02-15
影响因子：
4.4
通讯作者：
Hermann, Dirk M.
中科院分区：
文献类型：
--
作者：
Bacigaluppi, Marco;Pluchino, Stefano;Hermann, Dirk M.
在工业化国家，缺血性中风是第三大最常见的死亡原因，到目前为止，治疗选择仅限于疾病发作后的头几个小时。细胞移植已经出现在包括实验性中风在内的各种神经疾病中，作为一种成功的促进康复的方法，在急性中风后阶段也是如此。然而，在设想将这种有希望的基于细胞的方法移植到人类之前，我们仍然需要澄清：(I)理想的移植细胞来源，(Ii)最合适的细胞给药途径，以及(Iii)实现移植细胞与宿主组织适当和功能整合的最佳方法。在这里，我们特别强调神经干细胞/前体细胞，讨论可能涉及基于细胞的治疗在中风中的作用的潜在机制。(C)2007 Elsevier B.V.保留所有权利。
In ischemic stroke, the third most frequent cause of mortality in industrialized countries, therapeutic options have until now been limited to the first hours after disease onset. Cell transplantation has emerged in various neurological disorders, including experimental stroke, as a successful recovery-promoting approach also in the post-acute stroke phase. However, before envisaging any translation into humans of such promising cell-based approaches we still need to clarify: (i) the ideal cell source for transplantation, (ii) the most appropriate route of cell administration, and, last but not least, (iii) the best approach to achieve an appropriate and functional integration of transplanted cells into the host tissue. Here we discuss, with special emphasis on neural stem/precursor cells, potential mechanisms that may be involved in the action of cell-based therapies in stroke. (C) 2007 Elsevier B.V. All rights reserved.