Overlapping functions of the cell adhesion molecules Nr-CAM and L1 in cerebellar granule cell development.
Overlapping functions of the cell adhesion molecules Nr-CAM and L1 in cerebellar granule cell development.
复制标题
DOI：
10.1083/jcb.200104122
复制
发表时间：
2001-09-17
期刊：
影响因子：
--
通讯作者：
Grumet M
中科院分区：
文献类型：
--
作者：
Sakurai T;Lustig M;Babiarz J;Furley AJ;Tait S;Brophy PJ;Brown SA;Brown LY;Mason CA;Grumet M
The structurally related cell adhesion molecules L1 and Nr-CAM have overlapping expression patterns in cerebellar granule cells. Here we analyzed their involvement in granule cell development using mutant mice. Nr-CAM–deficient cerebellar granule cells failed to extend neurites in vitro on contactin, a known ligand for Nr-CAM expressed in the cerebellum, confirming that these mice are functionally null for Nr-CAM. In vivo, Nr-CAM–null cerebella did not exhibit obvious histological defects, although a mild size reduction of several lobes was observed, most notably lobes IV and V in the vermis. Mice deficient for both L1 and Nr-CAM exhibited severe cerebellar folial defects and a reduction in the thickness of the inner granule cell layer. Additionally, anti-L1 antibodies specifically disrupted survival and maintenance of Nr-CAM–deficient granule cells in cerebellar cultures treated with antibodies. The combined results indicate that Nr-CAM and L1 play a role in cerebellar granule cell development, and suggest that closely related molecules in the L1 family have overlapping functions.
登录
查看更多内容
DOI：
10.1083/jcb.137.3.703
发表时间：
1997-05-05
期刊：
The Journal of cell biology
影响因子：
--
作者：
Garver TD;Ren Q;Tuvia S;Bennett V
通讯作者：
Bennett V
影响因子：
2.7
作者：
Auerbach, W;Dunmore, JH;Joyner, AL
通讯作者：
Joyner, AL
Ranvier节点的分子组成：在淋巴结段鉴定Ankyrin结合细胞粘附分子神经胶质素（粘蛋白+/第三FNIII结构域）和NRCAM。
DOI：
10.1083/jcb.135.5.1355
发表时间：
1996-12
期刊：
The Journal of cell biology
影响因子：
--
作者：
Davis JQ;Lambert S;Bennett V
通讯作者：
Bennett V
影响因子：
7.8
作者：
Buchstaller, A;Kunz, S;Sonderegger, P
通讯作者：
Sonderegger, P
影响因子：
16.2
作者：
BAPTISTA, CA;HATTEN, ME;MASON, CA
通讯作者：
MASON, CA