Chiral separations of indan, tetralin and benzosuberan derivatives by capillary electrophoresis
Chiral separations of indan, tetralin and benzosuberan derivatives by capillary electrophoresis
复制标题
通过毛细管电泳手性分离茚满、四氢化萘和苯并苏苯衍生物
DOI：
10.1016/s0021-9673(97)00802-9
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发表时间：
1998
影响因子：
4.1
通讯作者：
D. Armstrong
中科院分区：
文献类型：
--
作者：
K. Gahm;J. Lee;Lisa W. Chang;D. Armstrong
用硫酸化β-环糊精（CD）或硫酸化β-CD与γ-CD的混合物作为手性添加剂，对不同极性的茚满、四氢萘和苯并环戊二烯衍生物进行了毛细管电泳手性拆分。硫酸化β-CD和羟丙基β-CD的混合物也成功地用于一些具有两个立体中心的四氢萘衍生物的对映体和非对映体分离。中性和阴离子分析物都在反向电泳极性模式下解决。茚满和四氢萘的阳离子氨基衍生物在常规的极性电泳模式下进行对映体拆分。
Several indan, tetralin and benzosuberan derivatives of diverse polarities were enantio-resolved by the use of sulfated β-cyclodextrins (CDs) or mixtures of sulfated β-CDs and γ-CD as chiral additives in capillary electrophoresis. Mixtures of sulfated β-CDs and hydroxypropyl β-CDs were also successfully utilized for enantiomeric and diastereomeric separations of some of the tetralin derivatives with two stereogenic centers. Both neutral and anionic analytes were resolved in the reversed electrophoretic polarity mode. Cationic amino derivatives of indan and tetralin were enantio-resolved in the conventional electrophoretic polarity mode.