Evidence for association of SNPs in ABCB1 and CBR3, but not RAC2, NCF4, SLC28A3 or TOP2B, with chronic cardiotoxicity in a cohort of breast cancer patients treated with anthracyclines
Evidence for association of SNPs in ABCB1 and CBR3, but not RAC2, NCF4, SLC28A3 or TOP2B, with chronic cardiotoxicity in a cohort of breast cancer patients treated with anthracyclines
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DOI：
10.2217/pgs.15.162
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发表时间：
2016-01-01
期刊：
影响因子：
2.1
通讯作者：
Rae, James M.
中科院分区：
文献类型：
--
作者：
Hertz, Daniel L.;Caram, Megan V.;Rae, James M.
验证RAC 2、NCF 4和SLC 28 A3中SNP的关联，鉴定与TOP 2B SNP的新关联，并筛选与蒽环类药物诱导的心脏毒性相关的23个SNP。患者和方法：共有166例接受阿霉素治疗的乳腺癌患者接受了超声心动图检查，其中19例患者出现收缩功能障碍（射血分数0.05），可能是由于功率不足。在未校正的二次分析中发现了两个SNP，包括ABCB 1中的保护性SNP（3435 C> T，p = 0.049）和CBR 3中的风险等位基因（V244 M，p = 0.012）。结论：先前出版物中报告的相关性和本次二次分析中发现的相关性需要在独立队列中进一步复制。
Validation of associations for SNPs in RAC2, NCF4 and SLC28A3, identification of a novel association with a TOP2B SNP and screening 23 SNPs putatively relevant to anthracycline-induced cardiotoxicity. Patients & methods: A total of 166 breast cancer patients treated with doxorubicin underwent echocardiogram, including 19 cases with systolic dysfunction (ejection fraction 0.05), likely due to inadequate power. Two SNPs were identified in the uncorrected secondary analysis including a protective SNP in ABCB1 (3435C> T, p = 0.049) and a risk allele in CBR3 (V244M, p = 0.012). Conclusion: The associations reported in prior publications and those discovered in this secondary analysis require further replication in independent cohorts.