The effects of vasopressin deficiency on aggression and impulsiveness in male and female rats
The effects of vasopressin deficiency on aggression and impulsiveness in male and female rats
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DOI：
10.1016/j.psyneuen.2014.05.010
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发表时间：
2014-09-01
影响因子：
3.7
通讯作者：
Haller, Jozsef
中科院分区：
文献类型：
--
作者：
Fodor, Anna;Barsvari, Beata;Haller, Jozsef
近年来，加压素在攻击行为中的作用受到广泛关注。然而，加压素对社会行为具有复杂的作用，受到社会经验、动机和激素背景的影响，表明其作用取决于受试者的状况。通过研究加压素缺乏对生殖幼稚和生殖经验丰富的男性以及哺乳期女性攻击性的影响，特别是攻击行为的模式和背景，检验了这一假设。我们还研究了对冲动的影响，冲动是一种与攻击性密切相关的行为特征。加压素缺乏不会影响有生育经验的男性的攻击性，降低了没有生育经验的男性的暴力攻击比例，但不影响攻击总数，并抑制哺乳早期和晚期的母亲攻击性；暴力形式的攻击在后一阶段有所减少，但在前一阶段却没有减少。攻击性的变化似乎与母亲行为的一般变化无关。哺乳期女性中，加压素缺乏会显着降低延迟贴现任务中的冲动性，但男性则不然。总而言之，我们的研究结果证实，加压素对攻击性有影响，但表明这种影响取决于受试者的状况，并表明加压素对母亲攻击性的影响与冲动有关。有趣的是，对攻击性的总体影响和对暴力攻击的具体影响在男性和女性中都是分离的，这暗示加压素在攻击性升级形式的发展中具有独特作用的可能性。 (C) 2014 Elsevier Ltd. 保留所有权利。
The role of vasopressin in aggression received much attention in recent years. However, vasopressin has complex roles on social behavior, which are affected by social experience, motivation and hormonal background, suggesting that its effects depend on the condition of subjects. This hypothesis was tested here by studying the impact of vasopressin deficiency on aggressiveness in reproductively naive and reproductively experienced males, as well as in Lactating females, with special reference to the patterns and contexts of attack behavior. We also studied effects on impulsiveness, a behavioral feature strongly related to aggression. Vasopressin deficiency did not affect aggressiveness in reproductively experienced males, decreased the share of violent attacks in reproductively inexperienced males without affecting total attack counts, and suppressed maternal aggression in both early and late phases of lactation; violent forms of attack were decreased in the latter but not the former phase. Changes in aggression appeared unrelated to general changes in maternal behaviors. Impulsivity in the delay discounting task was markedly decreased by vasopressin deficiency in lactating females but not males. Taken together, our findings confirm that vasopressin has an impact on aggressiveness, but show that this impact depends on the condition of subjects, and suggest that the effects of vasopressin on maternal aggression develop in conjunction with impulsivity. Interestingly, overall effects on aggression and specific effects on violent attacks dissociated in both males and females, which hints to the possibility that vasopressin has distinct roles in the development of escalated forms of aggression. (C) 2014 Elsevier Ltd. All rights reserved.