Regulation of anti-apoptotic BCL2-proteins by non-canonical interactions: The next step forward or two steps back?
Regulation of anti-apoptotic BCL2-proteins by non-canonical interactions: The next step forward or two steps back?
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DOI：
10.1002/jcb.23335
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发表时间：
2012-01-01
影响因子：
4
通讯作者：
Beverly, Levi J.
中科院分区：
文献类型：
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作者：
Beverly, Levi J.
细胞生物学的所有方面都影响着受调控的细胞死亡或凋亡的过程，而这一过程的破坏是许多疾病的致病事件。因此，全面了解调节细胞凋亡的所有途径将增加我们对基本细胞功能以及许多疾病病因的认识。反过来，我们也许能够利用这些知识来更好地治疗包括癌症在内的疾病患者。虽然调控细胞凋亡的基本信号通路已经被发现了10多年，但我们对直接调控核心细胞凋亡机制的上游信号通路仍有很多需要了解的地方。这篇综述的重点将是关注bcl2蛋白家族的非规范调节因子，特别是我们对这种相互作用的理解的空白，以及围绕一些这种相互作用的争议。j .细胞。生物化学学报，32(3):391 - 391。(C) 2011 Wiley期刊公司
All aspects of cellular biology affect the process of regulated cell death, or apoptosis, and disruption of this process is a causative event in many diseases. Therefore, a comprehensive understanding of all pathways that regulate apoptosis would increase our knowledge of basic cellular functions, as well as the etiologies of many diseases. In turn, we may be able to use this knowledge to better treat patients with diseases, including cancer. Although the basic signaling pathway that regulates apoptosis has been known for over 10 years, we still have much to learn about the upstream signaling components that can directly regulate the core apoptosis machinery. The focus of this review will be to direct attention to non-canonical regulators of the BCL2-family of proteins, especially our void of understanding of such interactions, and the controversy that surrounds some such interactions. J. Cell. Biochem. 113: 312, 2012. (C) 2011 Wiley Periodicals, Inc.