Lung function, airway inflammation, and polycyclic aromatic hydrocarbons exposure in mexican schoolchildren: a pilot study.
Lung function, airway inflammation, and polycyclic aromatic hydrocarbons exposure in mexican schoolchildren: a pilot study.
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DOI：
10.1097/jom.0000000000000111
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发表时间：
2014-04
影响因子：
3.2
通讯作者：
Romieu I
中科院分区：
文献类型：
--
作者：
Barraza-Villarreal A;Escamilla-Nuñez MC;Schilmann A;Hernandez-Cadena L;Li Z;Romanoff L;Sjödin A;Del Río-Navarro BE;Díaz-Sanchez D;Díaz-Barriga F;Sly P;Romieu I
确定墨西哥学童暴露于多环芳烃（PAHs）与肺功能和呼出冷凝水（EBC） pH值的关系。在墨西哥城的64名学童中进行了一项试点研究。测定肺功能和EBC pH值，测定尿样中多环芳烃的代谢物。使用稳健回归模型分析这种关联。2-羟基芴浓度增加10%与1秒内用力呼气量（- 11.2 mL, 95% CI: - 22.2至- 0.02）、用力肺活量（- 11.6 mL, 95% CI: - 22.9至- 0.2）和EBC pH （- 0.035, 95% CI: - 0.066至- 0.005）呈显著负相关。多环芳烃暴露的生物标志物与肺功能和EBC ph值下降呈负相关，这是墨西哥学童气道炎症的标志。
To determine the association of exposure to polycyclic aromatic hydrocarbons (PAHs) with lung function and pH of exhaled breath condensate (EBC) in Mexican schoolchildren. A pilot study was performed in a subsample of 64 schoolchildren from Mexico City. Lung function and pH of EBC were measured and metabolites of PAHs in urine samples were determined. The association was analyzed using robust regression models. A 10% increase in the concentrations of 2-hydroxyfluorene was significantly negatively associated with forced expiratory volume in 1 second (−11.2 mL, 95% CI: −22.2 to −0.02), forced vital capacity (−11.6 mL, 95% CI: −22.9 to −0.2), and pH of EBC (−0.035, 95% CI: −0.066 to −0.005). Biomarkers of PAHs exposure were inversely associated with lung function and decrease of ph of EBC as a marker of airway inflammation in Mexican schoolchildren.