Asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles via intramolecular trapping of chiral aza-ortho-xylylene
Asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles via intramolecular trapping of chiral aza-ortho-xylylene
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DOI：
10.1039/c3cc45369c
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发表时间：
2013-01-01
影响因子：
4.9
通讯作者：
Lu, Yixin
中科院分区：
文献类型：
--
作者：
Dou, Xiaowei;Yao, Weijun;Lu, Yixin
从3-氯-3-取代羟吲哚前体有效地生成手性氮杂邻苯二甲撑中间体。手性氮杂邻苯二甲基中间体的第一次分子内捕获导致了3-螺环丙基-2-羟吲哚的高度不对称合成。
Chiral aza-ortho-xylylene intermediates were efficiently generated from 3-chloro-3-substituted oxindole precursors. The first intramolecular trapping of chiral aza-ortho-xylylene intermediates led to a highly asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles.