The role of the RAS in programming of adult hypertension
The role of the RAS in programming of adult hypertension
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DOI：
10.1111/j.1365-201x.2004.01328.x
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发表时间：
2004-08-01
期刊：
影响因子：
--
通讯作者：
Woods, LL
中科院分区：
文献类型：
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作者：
Rasch, R;Skriver, E;Woods, LL
心血管疾病的病因学最初包括两个组成部分：遗传组成部分和环境或生活方式组成部分。在过去的几十年里，越来越多的流行病学证据表明了第三个组成部分的重要性：胎儿发育过程中环境的影响。尽管生活条件较好，但恶劣的生活条件导致婴儿死亡率高，并影响成年后心血管疾病的发病率（A。福斯达尔Br J Prev Soc Med 1977; 31，91-95）。据报道，产前生长模式与成年期心血管疾病死亡率之间存在关联（D. J. Barker，P.D.温特角，澳-地奥斯蒙德，B。Margetts & S.J. Simmonds. Lancet 1989; 2，577-580）。来自英国哈特福德郡的男性，出生于1911年至1930年。调查显示，出生时和1岁时体重最低的男性死于心血管疾病的风险最高（D. J. Barker，P.D.温特角，澳-地奥斯蒙德，B。Margetts & S.J. Simmonds. Lancet 1989; 2，577-580）。这些研究结果表明，与出生时体重正常的人相比，围产期环境中的因素可能会使一个人更晚患心血管疾病的风险。此后，许多研究证实了早期生长模式与成年期心血管疾病之间呈反比关系的初步发现。
The aetiology of cardiovascular disease originally included two components: a genetic component and an environmental or lifestyle component. Increasing epidemiologic evidence has been accumulating during the last decades indicating the importance of a third component: the influence of the environment during foetal development. Poor living conditions resulted in a high infant mortality and influenced the incidence of cardiovascular diseases in adulthood despite better living conditions (A. Forsdahl. Br J Prev Soc Med 1977; 31, 91-95). An association between pre-natal growth pattern and the rate of death from cardiovascular disease in adulthood was reported (D.J. Barker, P.D. Winter, C. Osmond, B. Margetts & S.J. Simmonds. Lancet 1989; 2, 577-580). Men from Hartfordshire (UK), born between 1911 and 1930 were investigated. The investigations showed that men with the lowest weight at birth and at 1 year of age had the highest risks of death from cardiovascular disease (D.J. Barker, P.D. Winter, C. Osmond, B. Margetts & S.J. Simmonds. Lancet 1989; 2, 577-580). These findings suggested that factors in the perinatal environment could programme an individual for later risk of development of cardiovascular disease compared with someone born with a normal weight. Numerous studies have since confirmed these initial findings of an inverse relationship between early growth pattern and cardiovascular disease in adulthood.