Short interspersed element (SINE) depletion and long interspersed element (LINE) abundance are not features universally required for imprinting.
Short interspersed element (SINE) depletion and long interspersed element (LINE) abundance are not features universally required for imprinting.
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DOI：
10.1371/journal.pone.0018953
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发表时间：
2011-04-20
期刊：
影响因子：
3.7
通讯作者：
Schulz R
中科院分区：
文献类型：
--
作者：
Cowley M;de Burca A;McCole RB;Chahal M;Saadat G;Oakey RJ;Schulz R
基因组印记是基因剂量调节的一种形式，其中基因仅从一个等位基因以依赖于起源亲本的方式表达。印迹基因表达的调控机制已被详细研究，并极大地促进了我们对基因组调控的理解。DNA序列特征（如CpG岛）和表观遗传特征（如DNA甲基化和非编码RNA）在实现印迹表达中起重要作用。然而，这些因素的相对重要性因地点而异。定义印记所必需的最小特征将有助于我们理解印记是如何机械地进化的。印记逆转录基因是印记基因座的一个子集，其基因组结构相对简单，与大的印记簇不同，并且有可能用作解决这个问题的工具。在这里，我们比较了重复元件的内容，具有类似的基因座组织的非印迹控制的印记逆转录基因座。我们没有观察到小鼠和人之间保守的显著差异，这表明其他人报道的印迹位点处西内斯的缺乏和LINES的相对丰度不是印迹普遍需要的序列特征。
Genomic imprinting is a form of gene dosage regulation in which a gene is expressed from only one of the alleles, in a manner dependent on the parent of origin. The mechanisms governing imprinted gene expression have been investigated in detail and have greatly contributed to our understanding of genome regulation in general. Both DNA sequence features, such as CpG islands, and epigenetic features, such as DNA methylation and non-coding RNAs, play important roles in achieving imprinted expression. However, the relative importance of these factors varies depending on the locus in question. Defining the minimal features that are absolutely required for imprinting would help us to understand how imprinting has evolved mechanistically. Imprinted retrogenes are a subset of imprinted loci that are relatively simple in their genomic organisation, being distinct from large imprinting clusters, and have the potential to be used as tools to address this question. Here, we compare the repeat element content of imprinted retrogene loci with non-imprinted controls that have a similar locus organisation. We observe no significant differences that are conserved between mouse and human, suggesting that the paucity of SINEs and relative abundance of LINEs at imprinted loci reported by others is not a sequence feature universally required for imprinting.
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DOI：
10.1073/pnas.0831042100
发表时间：
2003-04-29
影响因子：
11.1
作者：
Brouha, B;Schustak, J;Kazazian, HH
通讯作者：
Kazazian, HH
影响因子：
4.5
作者：
Kanber D;Berulava T;Ammerpohl O;Mitter D;Richter J;Siebert R;Horsthemke B;Lohmann D;Buiting K
通讯作者：
Buiting K
影响因子：
4.4
作者：
DeBerardinis, RJ;Kazazian, HH
通讯作者：
Kazazian, HH
影响因子：
10.5
作者：
Chotalia, Mita;Smallwood, Sebastien A.;Kelsey, Gavin
通讯作者：
Kelsey, Gavin
肿瘤抑制基因的转录和组织特异性印记。
影响因子：
3.5
作者：
Schulz R;McCole RB;Woodfine K;Wood AJ;Chahal M;Monk D;Moore GE;Oakey RJ
通讯作者：
Oakey RJ