THE ROLE OF HIGH-DENSITY-LIPOPROTEIN AND LIPID-SOLUBLE ANTIOXIDANT VITAMINS IN INHIBITING LOW-DENSITY-LIPOPROTEIN OXIDATION
THE ROLE OF HIGH-DENSITY-LIPOPROTEIN AND LIPID-SOLUBLE ANTIOXIDANT VITAMINS IN INHIBITING LOW-DENSITY-LIPOPROTEIN OXIDATION
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DOI：
10.1042/bj2940829
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发表时间：
1993-09-15
影响因子：
4.1
通讯作者：
DURRINGTON, PN
中科院分区：
文献类型：
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作者：
MACKNESS, MI;ABBOTT, C;DURRINGTON, PN
1.低密度脂蛋白（LDL）的氧化被认为在动脉粥样硬化形成中起核心作用。我们比较了抗氧化维生素和高密度脂蛋白（HDL）对Cu 2+催化氧化LDL的影响。2.抗氧化剂维生素的补充显着减少共轭二烯的形成，但不影响脂质过氧化物的形成。3.相反，HDL不影响共轭二烯的形成，但抑制脂质过氧化物的形成高达90%。4. HDL对氧化LDL中脂质过氧化物形成的抑制作用依赖于HDL的浓度，而不是由于HDL螯合Cu ~（2+）。5.自体HDL抑制脂质过氧化物形成的个体间差异很大，这与LDL中脂质过氧化物生成的速率有关。6.我们的结论是，HDL是一种强大的抗氧化剂或更可能抑制LDL氧化在体外，并可能在体内发挥重要作用，通过抑制LDL氧化在动脉壁中，在预防动脉粥样硬化。
1. The oxidation of low-density lipoprotein (LDL) is believed to play a central role in atherogenesis. We have compared the effect of antioxidant vitamins and high-density lipoprotein (HDL) on the Cu2+-catalysed oxidation of LDL. 2. Antioxidant vitamin supplementation significantly reduced conjugated diene formation but did not affect the formation of lipid peroxides. 3. Conversely, HDL did not affect conjugated diene formation but inhibited the formation of lipid peroxides by up to 90 %. 4. The inhibition by HDL of lipid peroxide formation in oxidized LDL was dependent on the concentration of HDL and was not due to HDL chelating Cu2+. 5. Large interindividual variations in the inhibition of lipid peroxide formation by autologous HDL were evident, which were related to the rate of lipid peroxide generation in the LDL. 6. We conclude that HDL is a powerful antioxidant or more probably inhibitor of LDL oxidation in vitro and may play an important role in vivo in preventing atherosclerosis by inhibiting LDL oxidation in the artery wall.