Cerebellar transcranial direct current stimulation modulates the effect of cerebellar transcranial magnetic stimulation on the excitability of spinal reflex
Cerebellar transcranial direct current stimulation modulates the effect of cerebellar transcranial magnetic stimulation on the excitability of spinal reflex
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DOI：
10.1016/j.neures.2019.01.012
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发表时间：
2020-01-01
影响因子：
2.9
通讯作者：
Okada, Yohei
中科院分区：
文献类型：
--
作者：
Matsugi, Akiyoshi;Okada, Yohei
小脑经颅磁刺激 (C-TMS) 促进同侧比目鱼肌 H 反射，反映脊髓运动神经元池的兴奋性。本研究旨在探讨 C-TMS 对脊髓运动神经元池兴奋性的促进是否受到小脑经颅直流电刺激 (ctDCS) 以极性特异性方式的影响。十一名健康成年人参与了这项研究。 H 反射是通过右胫神经的电刺激从右比目鱼肌测量的。在刺激胫神经之前 110 毫秒，对右侧小脑进行调节 TMS。 H 反射比率计算为条件/非条件 H 反射幅度，并在阳极、阴极或假右 ctDCS 前或后进行测量，电流为 2 mA，持续 15 分钟。结果表明，阳极 ctDCS 显着增加了 H 反射比率，阴极 ctDCS 降低了 H 反射比率，并且不受假 ctDCS 的影响，表明 ctDCS 以极性特异性方式调节 C-TMS 对 H 反射的影响。这意味着C-TMS对脊髓运动神经元池的影响受到小脑兴奋性变化的影响。 (C) 2019 Elsevier B.V. 和日本神经科学学会。版权所有。
Cerebellar transcranial magnetic stimulation (C-TMS) facilitates the ipsilateral soleus H-reflex, which reflects the excitability of the spinal motoneuron pool. This study aimed to investigate whether this facilitation of the spinal motoneuron pool excitability by C-TMS is affected by cerebellar transcranial direct current stimulation (ctDCS) in a polarity-specific manner. Eleven healthy adults participated in this study. The H-reflex was measured from the right soleus muscle by electrical stimulation of the right tibial nerve. The conditioning TMS over the right cerebellum was delivered 110ms before tibial nerve stimulation. The H-reflex ratio was calculated as conditioned/unconditioned H-reflex amplitude, and measured for pre- or post-anodal, cathodal, or sham right ctDCS, for 15 min with 2 mA. The results showed that the H-reflex ratio was significantly increased by anodal ctDCS, reduced by cathodal ctDCS, and not affected by sham ctDCS, indicating that the effect of C-TMS on the H-reflex is modulated by ctDCS in a polarity-specific manner. This implies that the effect of C-TMS on the spinal motoneuron pool is affected by the change in excitability of the cerebellum. (C) 2019 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.