Regulation of CD40 signaling in colon cancer cells and its implications in clinical tissues
Regulation of CD40 signaling in colon cancer cells and its implications in clinical tissues
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结肠癌细胞中 CD40 信号传导的调控及其对临床组织的影响
DOI：
10.1007/s00262-016-1847-0
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发表时间：
2016-06
影响因子：
5.8
通讯作者：
Li, Xiao-an
中科院分区：
文献类型：
--
作者：
Zhou, Yan;Zhou, Shu-xian;Gao, Long;Li, Xiao-an
CD 40是肿瘤坏死因子受体家族的成员。我们在这里揭示了CD 40表达和结肠癌分化之间的相关性。与CD 40配体（CD 40 L）结合后，CD 40/CD 40 L信号传导抑制结肠癌增殖，诱导细胞凋亡，使细胞停滞在G 0/G1期，并影响细胞粘附和转移。聚类分析表明，芳烃受体阻遏物（AHRR）表达的升高沿着CD 40/CD 40 L信号转导的激活。对临床标本的检查显示，AHR和AHRR水平与结肠癌组织学分级相关。此外，AHRR的高表达与肿瘤细胞中CD 40的高表达相关，其中CD 40 L的表达在肿瘤组织中特别高。Real-time PCR和Western blotting分析显示，CD 40 L结合可上调结肠癌细胞AHRR的表达。本文描述了CD 40作用的可能介导信号传导途径。
CD40 is a member of the tumor necrosis factor receptor family. We reveal here a correlation between CD40 expression and colon cancer differentiation. Upon CD40 ligand (CD40L) binding, CD40/CD40L signaling inhibited colon cancer proliferation, induced apoptosis, stalled cells at G0/G1, and influenced cell adhesion and metastasis. Clustering analysis identified the elevation of aryl hydrocarbon receptor repressor (AHRR) expression along with activation of CD40/CD40L signaling. Examination of clinical specimens revealed that both AHR and AHRR levels correlated with colon cancer histological grade. In addition, high expression of AHRR was associated with high expression of CD40 in tumor cells, with CD40L expression being particularly high in the tumor interstitium. Real-time PCR and western blotting analysis showed that AHRR expression in colon cancer cells was up-regulated by CD40L binding. The likely mediating signaling pathways for the effects of CD40 are described herein.
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DOI：
10.1097/01.fpc.0000054093.48725.79
发表时间：
2003-06
期刊：
Pharmacogenetics
影响因子：
--
作者：
S. Cauchi;I. Stücker;S. Cénée;P. Kremers;P. Beaune;L. Massaad-Massade
通讯作者：
S. Cauchi;I. Stücker;S. Cénée;P. Kremers;P. Beaune;L. Massaad-Massade
影响因子：
7.8
作者：
Ma DY;Clark EA
通讯作者：
Clark EA
DOI：
10.4049/jimmunol.0903229
发表时间：
2010-12
期刊：
The Journal of Immunology
影响因子：
--
作者：
Shuchismita R. Satpathy;Gautam N. Shenoy;Sheetal Kaw;Tushar Vaidya;V. Bal;S. Rath;A. George
通讯作者：
Shuchismita R. Satpathy;Gautam N. Shenoy;Sheetal Kaw;Tushar Vaidya;V. Bal;S. Rath;A. George
DOI：
10.1007/s00262-011-1194-0
发表时间：
2012-03
期刊：
Cancer Immunology, Immunotherapy
影响因子：
--
作者：
Yan Zhou;Jing He;L. Gou;Bo Mu;Wei-chan Liao;Cong Ma;Ping Tang;Shijie Zhou;Yong-jun Zhou;Jin-liang Yang
通讯作者：
Yan Zhou;Jing He;L. Gou;Bo Mu;Wei-chan Liao;Cong Ma;Ping Tang;Shijie Zhou;Yong-jun Zhou;Jin-liang Yang
影响因子：
8.7
作者：
Elgueta R;Benson MJ;de Vries VC;Wasiuk A;Guo Y;Noelle RJ
通讯作者：
Noelle RJ