Probiotic and prebiotic supplementation for the prevention of neonatal necrotizing enterocolitis
Probiotic and prebiotic supplementation for the prevention of neonatal necrotizing enterocolitis
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DOI：
10.1038/jp.2009.21
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发表时间：
2009-05-01
影响因子：
2.9
通讯作者：
Caplan, M. S.
中科院分区：
文献类型：
--
作者：
Caplan, M. S.
坏死性小肠结肠炎 (NEC) 的病理生理学尚未明确阐明，但最近的研究支持不平衡的促炎信号传导的作用，导致早产儿肠坏死。尽管母乳喂养被认为可以降低这种疾病的风险，但目前还没有一致证明对这种常见且毁灭性的疾病有效的预防或治疗方法。最近的研究表明，早产儿的益生菌定植异常，肠内补充多种益生菌可以降低患病风险。本章总结了当前有关益生菌和 NEC 的最新技术，但建议谨慎行事，直到有适当监管的产品可用于这一高危人群。围产期杂志（2009）29，S2-S6； doi:10.1038/jp.2009.21
The pathophysiology of necrotizing enterocolitis (NEC) has not been clearly elucidated, but recent studies support the role of unbalanced pro-inflammatory signaling, leading to intestinal necrosis in premature infants. Although breast milk feeding is thought to reduce the risk of this condition, there are no preventive or therapeutic approaches that have consistently shown to be effective for this common and devastating disease. Recent studies show that probiotic colonization is abnormal in preterm neonates, and enteral supplementation with a variety of probiotic organisms can reduce the risk of disease. This chapter summarizes the current state-of-the-art regarding probiotics and NEC, but suggests caution until appropriately regulated products are available for use in this high-risk population. Journal of Perinatology (2009) 29, S2-S6; doi:10.1038/jp.2009.21