Transmission fitness of drug-resistant human immunodeficiency virus and the prevalence of resistance in the antiretroviral-treated population
Transmission fitness of drug-resistant human immunodeficiency virus and the prevalence of resistance in the antiretroviral-treated population
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DOI：
10.1086/367989
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发表时间：
2003-02-15
影响因子：
6.4
通讯作者：
Little, SJ
中科院分区：
文献类型：
--
作者：
Brown, AJL;Frost, SDW;Little, SJ
尽管耐药菌株在北美原发性人类免疫缺陷病毒（HIV）感染中的流行率最近有所增加，但它们的传播适应性仍然未知。本研究通过对临床资料的回顾性调查，估计了接受抗逆转录病毒治疗的患者传播耐药艾滋病毒的频率。结果显示，耐药病毒在这些患者中传播的频率只有预期的20%。具有初抗性的个体可能成为耐药菌株的重要来源。
Although the prevalence of drug-resistant strains in primary human immunodeficiency virus (HIV) infection in North America has recently increased, their transmission fitness remains unknown. The present study estimated the frequency of transmission of drug-resistant HIV from patients receiving antiretroviral therapy using retrospective surveys of clinic data. It revealed that resistant virus was transmitted only similar to20% as frequently as expected from these patients. Individuals with primary resistance may become a significant source of resistant strains.