Phenolic glycosides from the rhizomes of Cyperus rotundus and their antidepressant activity
Phenolic glycosides from the rhizomes of Cyperus rotundus and their antidepressant activity
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香附根茎酚苷及其抗抑郁活性
DOI：
10.1007/s13765-015-0092-0
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发表时间：
2015-10-01
影响因子：
--
通讯作者：
Yin, Wen-qing
中科院分区：
文献类型：
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作者：
Lin, San-qing;Zhou, Zhong-liu;Yin, Wen-qing
抑郁症是患者最常见的精神合并症。从天然产物中寻找抗抑郁药物对于治疗该疾病非常重要。我们的小组评估了香附的乙醇提取物及其馏分对小鼠的抗抑郁活性。本研究的目的是研究 C. rotundus 的潜在活性成分。对 C. rotundus 根茎进行提取和溶剂分配，并重复柱层析 n-BuOH 组分，得到三种新的酚苷：rotunduside D (1)、rotunduside E (2) 和 rotunduside F (3)。它们的化学结构是根据NMR、MS、UV和IR等光谱数据分析确定的。评估了所有分离化合物的潜在抗抑郁活性。在绝望小鼠模型中，rotunduside F (3) 在 50 mg/kg 剂量下表现出显着的抗抑郁活性，接近阳性对照氟西汀 (20 mg/kg)。
Depression is the most common psychiatric comorbidity in patients. Searching for antidepressant drugs from natural products is very important for the treatment of this disease. The ethanol extract and its fractions of Cyperus rotundus were evaluated for antidepressant activities in mice by our group. The aim of this study was to investigate the potential active components of C. rotundus. The extraction and solvent partition of the rhizomes of C. rotundus, and repeated column chromatography for n-BuOH fraction yielded three new phenolic glycosides, rotunduside D (1), rotunduside E (2), and rotunduside F (3). Their chemical structures were identified on the basis of spectroscopic data analyses including NMR, MS, UV, and IR. The potential antidepressant activity of all the isolated compounds was evaluated. In the despair mice models, rotunduside F (3) showed significant antidepressant activity at the dosage of 50 mg/kg, which was close to the positive control fluoxetine (20 mg/kg).