Efficacy and Safety Assessments of Ferula assa-foetida L . , Traditionally used in Greco-Arab Herbal Medicine for Enhancing Male Fertility , Libido and Erectile Function
Efficacy and Safety Assessments of Ferula assa-foetida L . , Traditionally used in Greco-Arab Herbal Medicine for Enhancing Male Fertility , Libido and Erectile Function
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阿魏的功效和安全性评估。
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
O. Said
中科院分区：
文献类型：
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作者：
E. Kassis;S. Fulder;K. Khalil;Bahaa Hadieh;F. Nahhas;B. Saad;O. Said
基于阿拉伯和伊斯兰传统草药的知识，本研究旨在研究阿魏提取物对大鼠和人的雄性生育力和性功能的影响。因此，将种子的乙醇提取物和根的50%水-乙醇提取物制备成所谓的“男性”片剂，并评估其安全性和增强男性性欲的有效性。获得的结果表明，在培养的人成纤维细胞和大鼠的实验研究中，雄激素表现出高水平的安全性，LD 50为5 g/kg。浓度为50μg/ml时，大鼠肝细胞和人精子细胞中的抗氧化特性均显著。对有和没有内皮组织的大鼠动脉环的实验表明，由于对平滑肌细胞的内皮介导作用而不是直接作用，雄激素是一种有效的血管扩张剂。在两组大鼠中研究了阴茎勃起的发生，并且在雄激素治疗组中显著增加。此外，研究了两组健康的年轻男性，并跟踪了3个月，每天服用一片男性片剂。所有男性均耐受良好，未报告任何副作用。两组都是从生育诊所招募的，第一组（n = 60）是由于医学上无法治疗的不完全无精子症而招募的，第二组（n = 25）是由于无法治疗的勃起功能障碍和阳痿而招募的。治疗两个月后，第一组和第二组分别有17%和60%的精子数量和质量得到改善。此外，第二组中有60%的人报告说他们的性欲和勃起功能都有显着改善。总的来说，我们的研究结果表明，男性是一种安全的性补品，提高动物和人类的男性性功能。
Based on knowledge from traditional Arabic and Islamic herbal medicine, this study aims to examine the effects of extracts from Ferula assa-foetida L on male fertility and sexual functioning in rats and in man. Therefore, ethanol extract from seeds and 50% water-ethanol extracts from roots were prepared into so-called “Masculine” tablets and assessed for their safety and efficacy in enhancing male libido. Results obtained show that Masculine exhibit high levels of safety in both cultured human fibroblasts and in experimental studies on rats with a LD50 of 5 g/kg. Antioxidant properties were substantial both in rat liver cells and in human sperm cells at a concentration of 50μg/ml. Experiments with rat arterial rings with and without their endothelial tissue revealed, that Masculine is a potent vasodilator due to an endotheliamediated effect rather than a direct effect on smooth muscle cells. Episodes of penile erection were studied in two groups of rats and were significantly augmented in the Masculine treated group. Furthermore, two groups of healthy young men were studied and followed for 3 months while consuming one Masculine tablet daily. Masculine was well tolerated by all men and no side effects were reported. Both groups were recruited from fertility clinics, the first group (n = 60) was recruited due to incomplete azospermia that was medically untreatable, and the second group (n = 25) was recruited due to erectile dysfunction and impotence of no treatable cause. Quantitative and qualitative improvements of sperm counts were reported after two months of treatment in 17% and 60%, in the first and second group, respectively. In addition, 60% of the second group reported remarkable improvements in both their libido and erectile function. Taken collectively, our results indicate that Masculine is a safe sexual tonic enhancing male sexual functioning in animals and in man.