Ionizing Radiation Exposure and Basal Cell Carcinoma Pathogenesis.
Ionizing Radiation Exposure and Basal Cell Carcinoma Pathogenesis.
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DOI：
10.1667/rr4284.s1
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发表时间：
2016-03
影响因子：
3.4
通讯作者：
Athar M
中科院分区：
文献类型：
--
作者：
Li C;Athar M
这篇评论总结了显示基底细胞癌（BCC）发展风险与环境、职业和治疗暴露于电离辐射（IR）有关的研究。BCC是最常见的人类癌症类型，是由hedgehog （Hh）信号的异常激活驱动的。Ptch和Smoothened是Hh信号通路的抑癌基因，在辐射诱导的bcc动物模型中发挥关键作用。流行病学研究提供的证据表明，在原子弹幸存者、骨髓移植受者、头癣患者和放射工作人员的长期、大规模队列中观察到的暴露于辐射的人类增加了bcc的风险。总的来说，白种人的这种风险高于其他种族。在生命早期接触的人会有更多的bcc。增强的IR与BCC而非其他常见皮肤恶性肿瘤的相关性是有趣的。这些观察结果背后的机制尚不清楚。了解辐射诱导的信号通路与驱动BCC发展的信号通路之间的相互作用，对于揭示与这种风险增加相关的机制可能很重要。最近的研究表明，Vismodegib（一种Smoothened抑制剂）对治疗人类辐射诱导的bcc有效，这表明无论其病因如何，都需要共同的策略来干预bcc的发展。
This commentary summarizes studies showing risk of basal cell carcinoma (BCC) development in relationship to environmental, occupational and therapeutic exposure to ionizing radiation (IR). BCC, the most common type of human cancer, is driven by the aberrant activation of hedgehog (Hh) signaling. Ptch, a tumor suppressor gene of Hh signaling pathway, and Smoothened play a key role in the development of radiation-induced BCCs in animal models. Epidemiological studies provide evidence that humans exposed to radiation as observed among the long-term, large scale cohorts of atomic bomb survivors, bone marrow transplant recipients, patients with tinea capitis and radiologic workers enhances risk of BCCs. Overall, this risk is higher in Caucasians than other races. People who were exposed early in life develop more BCCs. The enhanced IR correlation with BCC and not other common cutaneous malignancies is intriguing. The mechanism underlying these observations remains undefined. Understanding interactions between radiation-induced signaling pathways and those which drive BCC development may be important in unraveling the mechanism associated with this enhanced risk. Recent studies showed that Vismodegib, a Smoothened inhibitor, is effective in treating radiation-induced BCCs in humans, suggesting that common strategies are required for the intervention of BCCs development irrespective of their etiology.