Minority recruitment to the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
Minority recruitment to the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
复制标题
DOI：
10.1191/1740774505cn111oa
复制
发表时间：
2005-01-01
期刊：
影响因子：
2.7
通讯作者：
Probstfield, JL
中科院分区：
文献类型：
--
作者：
Cook, ED;Moody-Thomas, S;Probstfield, JL
背景以前的大型化学预防研究没有招募大量的少数民族。硒和维生素E癌症预防试验（SELECT）是一项大型III期研究，评估硒和维生素E对前列腺癌临床发病率的影响。美国、加拿大和波多黎各的400多个SELECT研究中心招募了男性参加本试验。SELECT的招募目标是24%的少数族裔，20%的黑人，3%的西班牙裔和1%的亚洲参与者。方法SELECT中的少数族裔招募策略是：1）在研究中心选择时考虑少数族裔招募; 2）通过降低黑人男性的年龄标准和包括有控制的共病男性来扩大合格标准; 3）发展国家基础设施; 4）给予额外的资金，以网站的潜力，以增加黑人入学率;和5）提供资源，最大限度地利用免费媒体的机会，以促进选择。结果选择招聘开始于2001年8月，并打算持续五年，但结束了两年的时间表在2004年6月提前。在35534名参与者中，21%为少数民族，15%为黑人，5%为西班牙裔，1%为亚裔。结论：美国国家癌症研究所（NCI）、西南肿瘤组（SWOG）、SELECT招募和依从性委员会（RAC）、SELECT少数民族和医疗服务不足小组委员会（MMUS）和当地的SELECT网站导致提前达到估计的样本量，并招募了有史以来最大比例的黑人参与者随机参加癌症预防试验。
Background Previous large chemoprevention studies have not recruited significant numbers of minorities. The Selenium and Vitamin E Cancer Prevention Trial (SELECT) is a large phase III study evaluating the impact of selenium and vitamin E on the clinical incidence of prostate cancer. Over 400 SELECT study sites in the USA, Canada, and Puerto Rico recruited men to this trial. The SELECT recruitment goal was 24% minorities, with 20% black, 3% Hispanic, and 1% Asian participants. The goal for black participants was set at 20% because of their proportion in the United States population and their prevalence of prostate cancer.Methods The minority recruitment strategies in SELECT were to: 1) consider minority recruitment during site selection; 2) expand the eligibility criteria by lowering the age criterion for black men and including men with controlled co-morbid illnesses; 3) develop a national infrastructure; 4) give additional funds to sites with the potential to increase black enrollment; and 5) provide resources to maximize free media opportunities to promote SELECT.Results SELECT recruitment began in August 2001 and was intended to last five years, but concluded two years ahead of schedule in June 2004. Of the 35 534 participants enrolled, 21% were minorities, with 15% black, 5% Hispanic, and 1% Asian.Conclusions Careful planning, recruitment of large numbers of clinical centers and adequate resources accomplished by the combined efforts of the National Cancer Institute (NCl), Southwest Oncology Group (SWOG), SELECT Recruitment and Adherence Committee (RAC), SELECT Minority and Medically Underserved Subcommittee (MMUS), and the local SELECT sites resulted in attainment of the estimated sample size ahead of schedule and recruitment of the largest percentage of black participants ever randomized to a cancer prevention trial.