Urinary excretion of hippuric acid and m-methylhippuric acid after administration of toluene and m-xylene mixture to rats
Urinary excretion of hippuric acid and m-methylhippuric acid after administration of toluene and m-xylene mixture to rats
复制标题
大鼠给予甲苯和间二甲苯混合物后马尿酸和间甲基马尿酸的尿排泄
DOI：
10.1007/bf00454279
复制
发表时间：
1979
影响因子：
3
通讯作者：
T. Fujii
中科院分区：
文献类型：
--
作者：
M. Ogata;T. Fujii
摘要雄性 Wistar 大鼠腹膜内（i.p.）注射单独的甲苯、单独的间二甲苯以及两者的组合。从注射结束到48小时后，以适当的时间间隔，研究注射不同浓度溶剂的大鼠的马尿酸或间甲基马尿酸的尿排泄。同时注射甲苯和间二甲苯的大鼠0～24h尿样中HA和m-MHA排泄增加量不低于同量单次注射甲苯或单独注射间二甲苯的大鼠。数据表明，同时施用甲苯和间二甲苯不会显着干扰甲苯或间二甲苯的代谢。
SummaryMale Wistar rats were injected intraperitoneally (i.p.) with toluene alone, m-xylene alone, and in combination with both of them. Urinary excretion of hippuric acid or m-methylhippuric acid of rats injected with solvents of various concentrations was investigated from the end of the injections up to 48 h later, at appropriate intervals. The amounts of increased excretion of HA and m-MHA in 0–24h urine samples of the rats given simultaneous injections of toluene and m-xylene were not lower than those of the rats given single injections of toluene alone or m-xylene alone, in the same amount. Data indicated that simultaneous administration of toluene and m-xylene did not significantly interfere with the metabolism of toluene or m-xylene.