Association between γ′ fibrinogen levels and inflammation
Association between γ′ fibrinogen levels and inflammation
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DOI：
10.1160/th10-09-0626
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发表时间：
2011-04-01
影响因子：
6.7
通讯作者：
Farrell, David H.
中科院分区：
文献类型：
--
作者：
Alexander, Kristine S.;Madden, Theresa E.;Farrell, David H.
γ纤维蛋白原亚型产生的凝块比更常见的纤维蛋白原亚型γ A更硬，更耐分解。γ纤维蛋白原水平的增加与几种形式的心血管疾病有关。这项横断面研究的目的是调查γ纤维蛋白原（一种新出现的心血管疾病危险因素）与慢性炎症状态受试者的炎症标志物之间的关系。本研究的284名受试者来自牙周炎和血管事件（PAVE）研究，并且通过ELISA测量血浆中的γ纤维蛋白原和总纤维蛋白原。关于患者人口统计学和健康状况的信息，以及C-反应蛋白（CRP）（一种炎症标志物）的水平，先前已收集用于本研究。受试者的平均（SE）γ纤维蛋白原水平为0.622（0.017）mg/ml。γ纤维蛋白原水平与CRP相关（p = 0.006），校正潜在混杂因素后，CRP增加1个单位与γ纤维蛋白原增加1.9%相关。在这些受试者中，总纤维蛋白原与γ纤维蛋白原不相关。有组织炎症证据的牙齿部位的数量也与γ纤维蛋白原水平显著相关。这些结果提供了γ '纤维蛋白原不仅作为心血管疾病的一般风险因素，而且作为用于评估患者的炎症状态和相关心血管疾病风险的潜在有用的生物标志物的演变中的重要步骤。
The gamma' fibrinogen isoform produces clots that are stiffer and more resistant to breakdown than the more common fibrinogen isoform, gamma A. Increased levels of gamma' fibrinogen are associated with several forms of cardiovascular disease. The purpose of this cross-sectional study was to investigate the relationship between gamma' fibrinogen, an emerging risk factor for cardiovascular disease, and inflammatory markers in subjects with a chronic inflammatory state. The 284 subjects for this study came from the Periodontitis And Vascular Events (PAVE) study, and gamma' fibrinogen and total fibrinogen in plasma were measured by ELISA. Information on patient demographics and health status, as well as levels of C-reactive protein (CRP), an inflammatory marker, have previously been collected for this study. The mean (SE) gamma' fibrinogen level in the subjects was 0.622 (0.017) mg/ml. Levels of gamma' fibrinogen were correlated with CRP (p = 0.006), with a one unit increase in CRP associated with a 1.9% increase in gamma' fibrinogen, after adjustment for potential confounders. Total fibrinogen was not correlated with gamma' fibrinogen in these subjects. The number of dental sites with evidence of tissue inflammation was also significantly associated with gamma' fibrinogen levels. These results provide an important step in the evolution of gamma' fibrinogen not only as a general risk factor for cardiovascular disease, but as a potentially useful biomarker for assessing a patient's inflammatory state and associated cardiovascular disease risk.