Impaired acquisition of spatial memory 2 weeks after isoflurane and isoflurane-nitrous oxide anesthesia in aged rats
Impaired acquisition of spatial memory 2 weeks after isoflurane and isoflurane-nitrous oxide anesthesia in aged rats
复制标题
DOI：
10.1213/01.ane.0000135408.14319.cc
复制
发表时间：
2004-11-01
影响因子：
5.7
通讯作者：
Crosby, G
中科院分区：
文献类型：
--
作者：
Culley, DJ;Baxter, MG;Crosby, G
老年大鼠在异氟醚-一氧化二氮麻醉后至少24 - 48小时的空间记忆任务中受损。在这项研究中，我们测试了这种损害持续多久，并调查了一氧化二氮的作用。将18个月大的大鼠随机分配至1.2%异氟烷（含或不含70%一氧化二氮）或对照组（30%氧气）麻醉2小时。两周后，每天在12臂径向迷宫上测试大鼠，持续14天。记录第一次错误的正确选择数、总错误数和完成迷宫的时间。1.2%异氟醚+70%氧化亚氮麻醉组大鼠在第一次错误前正确选择次数较少（P <0.05）。注意到错误率和完成迷宫的时间有类似结果的趋势，但这些没有达到统计学显著性。比较所有麻醉大鼠与对照组的事后分析表明，麻醉大鼠对第一次错误做出的正确选择较少（P小于或等于0.05），完成迷宫所需的时间较长（P小于或等于0.05）。总错误数无差异（P ≤ 0.06）。因此，老年大鼠全身麻醉后2周的空间记忆受损，与是否使用一氧化二氮无关。
Aged rats are impaired on a spatial memory task for at least 24-48 h after isoflurane-nitrous oxide anesthesia. In this study, we tested how long the impairment lasts and investigated the role of nitrous oxide. Eighteen-month-old rats were randomized to anesthesia for 2 h with 1.2% isoflurane with or without 70% nitrous oxide or a control group (30% oxygen). Two weeks later, rats were tested daily for 14 days on a 12-arm radial maze. The number of correct choices to first error, total errors, and time to complete the maze were recorded. Rats anesthetized with 1.2% isoflurane with 70% nitrous oxide made fewer correct choices before first error (P less than or equal to 0.05). Trends toward similar results were noted for error rate and time to complete the maze, but these did not achieve statistical significance. Post hoc analysis comparing all anesthetized rats to controls demonstrated that anesthetized rats made fewer correct choices to first error (P less than or equal to 0.05) and took longer to complete the maze (P less than or equal to 0.05). There were no differences in total number of errors (P less than or equal to 0.06). Thus, spatial memory is impaired for 2 wk after general anesthesia in aged rats independent of whether nitrous oxide is used.