A comparison of risk factors for preterm labor and term small-for-gestational-age birth
A comparison of risk factors for preterm labor and term small-for-gestational-age birth
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DOI：
10.1097/00001648-199607000-00006
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发表时间：
1996-07-01
期刊：
影响因子：
5.4
通讯作者：
Cohen, A
中科院分区：
文献类型：
--
作者：
Lang, JM;Lieberman, E;Cohen, A
这项研究估计了23个因素在整个出生体重范围内对早产和胎儿生长迟缓患病率的影响。我们在胎龄合适的婴儿(N=9,490)范围内研究了早产的危险因素。我们还研究了足月儿(N=10,889)胎儿生长迟缓的危险因素。早产与孕妇年龄小、孕前体重低、每周体重增加低、未产、早产、两次或两次以上人工流产史、自然流产或死产、子宫暴露于己烯雌酚(DES)、宫颈功能不全、子宫畸形和肾盂肾炎独立相关。优势比从1.7到5.9不等。根据小于胎龄儿的出生估计，胎儿生长迟缓独立地与黑人种族、年轻孕妇年龄、母亲身高较低、孕前体重低、每周体重增加低、吸烟、未生育、先前早产、三次或更多流产、子宫异常和子宫暴露于DES有关。赔率比从1.6到2.8不等。我们的研究表明，区分不同的途径获得低出生体重，并考虑整个出生体重谱上不良妊娠结局的发生，对于病因学理解具有重要意义。这些发现加强了在妊娠结局研究中全面控制混淆的必要性。
This study estimates the effects of 23 factors on the prevalence of premature labor and fetal growth retardation across the entire birthweight spectrum. We studied risk factors for premature labor within the domain of babies of appropriate size for their gestational age (N = 9,490). We also studied risk factors for fetal growth retardation among babies born at term (N = 10,889). Preterm labor was associated independently with young maternal age, low prepregnant weight, low weekly weight gain, nulliparity, previous preterm birth, histories of two or more induced abortions, spontaneous abortions, or stillbirths, uterine exposure to diethylstilbestrol (DES), incompetent cervix, uterine anomaly, and pyelonephritis. Odds ratios ranged from 1.7 to 5.9. Fetal growth retardation, as estimated by small-for-gestational-age birth, was associated independently with black race, young maternal age, short maternal height, low prepregnancy weight, low weekly weight gain, and smoking, as well as nulliparity, previous preterm birth, three or more abortions, uterine anomaly, and uterine exposure to DES. Odds ratios ranged from 1.6 to 2.8. Our study shows the importance for etiologic understanding of separating diverse routes to low birthweight and considering the occurrence of adverse pregnancy outcomes along the entire birthweight spectrum. The findings reinforce the need for comprehensive control of confounding in studies of pregnancy outcome.