Rostral ventrolateral medulla as a site for the central hypertensive action of kinins.
Rostral ventrolateral medulla as a site for the central hypertensive action of kinins.
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延髓头端腹外侧区是激肽中枢高血压作用的部位。
DOI：
10.1161/01.hyp.23.1.52
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Yates,P
中科院分区：
文献类型：
--
作者：
Privitera,PJ;Thibodeaux,H;Yates,P
在本研究中，我们集中在延髓头端腹外侧作为激肽的一个可能的作用部位，因为它在心血管系统的中枢调节中的重要性。将100 pmol至4 nmol缓激肽单侧微量注射到延髓头端腹外侧区，可使SD大鼠、WKY大鼠和自发性高血压大鼠（SHR）的平均动脉压呈剂量依赖性升高。SD和WKY大鼠对缓激肽的高血压反应的剂量-反应曲线基本相同，而SHR中缓激肽的高血压效应显著大于SD或WKY大鼠。激肽B2受体拮抗剂D-Arg 0、Hyp 3、Thi 5，8、D-Phe 7-缓激肽和Hoe 140均能抑制缓激肽引起的SHR和WKY大鼠高血压反应。在4 nmol D-Arg 0，Hyp 3，Thi 5，8，D-Phe 7-缓激肽后，500 pmol缓激肽的高血压效应在SHR中降低了65 +/- 5%，在WKY大鼠中降低了50 +/- 16%，而1 nmol Hoe 140消除了500 pmol缓激肽注射到延髓头端腹外侧的高血压效应。微量注射D-Arg 0、Hyp 3、Thi 5，8、D-Phe 7-缓激肽可导致平均动脉压和心率呈剂量依赖性延长下降。SHR的血压下降70 +/- 8 mm Hg，心率下降49 +/- 9次/分钟，而WKY大鼠的平均动脉压下降12 +/- 4 mm Hg，心率没有变化。以类似的方式，Hoe 140分别使SHR和WKY大鼠的血压降低51 +/- 7和17 +/- 3 mm Hg。（250字处删节）
In the present study, we focused on the rostral ventrolateral medulla as a possible site of action for kinins because of its established importance in the central regulation of the cardiovascular system. Unilateral microinjections of 100 pmol to 4 nmol bradykinin into the rostral ventrolateral medulla produced dose-dependent increases in mean arterial pressure in Sprague-Dawley (SD) rats, Wistar-Kyoto (WKY) rats, and spontaneously hypertensive rats (SHR). The dose-response curves for the hypertensive responses to bradykinin in SD and WKY rats were essentially the same, whereas the hypertensive effect of bradykinin was significantly greater in SHR than in either SD or WKY rats. The kinin B2 receptor antagonists D-Arg0,Hyp3,Thi5,8,D-Phe7-bradykinin and Hoe 140 inhibited the hypertensive responses to bradykinin in both SHR and WKY rats. The hypertensive effect of 500 pmol bradykinin was reduced 65 +/- 5% after 4 nmol of D-Arg0, Hyp3,Thi5,8,D-Phe7-bradykinin in SHR and 50 +/- 16% in WKY rats, whereas 1 nmol Hoe 140 abolished the hypertensive effect of 500 pmol bradykinin injected into the rostral ventrolateral medulla. Microinjection of D-Arg0,Hyp3,Thi5,8,D-Phe7-bradykinin produced prolonged dose-dependent decreases in mean arterial pressure and heart rate. Blood pressure decreased 70 +/- 8 mm Hg and heart rate decreased 49 +/- 9 beats per minute in SHR, whereas in WKY rats mean arterial pressure decreased 12 +/- 4 mm Hg, with no change in heart rate. In a similar fashion, Hoe 140 caused a 51 +/- 7 and 17 +/- 3 mm Hg reduction in blood pressure in SHR and WKY rats, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)