Plasma arachidonic acid influences insulin-stimulated glucose uptake in healthy adult women
Plasma arachidonic acid influences insulin-stimulated glucose uptake in healthy adult women
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DOI：
10.1159/000111171
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发表时间：
2007-01-01
影响因子：
3.9
通讯作者：
Diaz, Erik O.
中科院分区：
文献类型：
--
作者：
Galgani, Jose E.;Aguirre, Carolina A.;Diaz, Erik O.
背景：脂肪酸可调节脂代谢，与胰岛素抵抗（IR）有关.本研究评估了健康女性血浆脂肪酸谱与IR、燃料氧化代谢和血脂浓度的关系。研究方法：16名“健康”、久坐和非肥胖的女性在空腹条件下进行了燃料氧化、血浆脂肪酸谱、游离脂肪酸、甘油三酯、葡萄糖和胰岛素浓度的评价。IR，燃料氧化和血脂测定胰岛素刺激条件下。使用斯皮尔曼检验评估相关变量之间的相关性。逐步多元回归分析，以确定主要的临床/代谢和脂肪酸的决定因素IR. Results：血浆花生四烯酸含量（%）确定IR，并结合胰岛素刺激的血浆甘油三酯浓度解释45%的IR方差。IR与体能呈负相关（rs =-0.48，p = 0.01）。后者与血浆饱和脂肪酸含量（%）呈负相关（rs =-0.48，p < 0.01），但与血浆二十二碳六烯酸含量（%）呈正相关（rs = 0.40，p = 0.04）。结论：支持特定脂肪酸影响IR的假设。血浆花生四烯酸与IR相关，独立于临床/代谢研究变量。二十二碳六烯酸和饱和脂肪酸可能通过调节线粒体氧化功能影响胰岛素的作用。版权所有（c）2007 S. Karger AG，巴塞尔。
Background: Fatty acids can modulate lipid metabolism, this is related to insulin resistance (IR). This study evaluated the relationship of plasma fatty acid profile with IR, fuel oxidative metabolism and plasma lipid concentration in 'healthy' women. Methods: Sixteen 'healthy', sedentary and non-obese women were evaluated under fasting conditions for fuel oxidation, plasma fatty acid profile, free fatty acids, triglycerides, glucose and insulin concentrations. IR, fuel oxidation and plasma lipids were measured under insulin-stimulated conditions. Using the Spearman test the correlation between relevant variables was assessed. Stepwise multiple regression analysis was done to identify the main clinical/metabolic and fatty acid determinants of IR. Results: Plasma arachidonic acid content (%) determined IR, and in combination with insulin-stimulated plasma triglyceride concentration explained 45% of the IR variance. IR was inversely related to physical fitness (rs = -0.48, p = 0.01). The latter was inversely associated to plasma saturated fatty acid content (%) ( rs = -0.48, p < 0.01), but directly associated to plasma docosahexaenoic acid content (%) ( rs = 0.40, p = 0.04). Conclusions: Support for the hypothesis that specific fatty acids influence IR is provided. Plasma arachidonic acid was associated to IR, independent on clinical/metabolic study variables. Docosahexaenoic and saturated fatty acids could potentially affect insulin action through modulating mitochondrial oxidative function. Copyright (c) 2007 S. Karger AG, Basel.