Tumor ablation due to inhomogeneous anisotropic diffusion in generic three-dimensional topologies
Tumor ablation due to inhomogeneous anisotropic diffusion in generic three-dimensional topologies
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DOI：
10.1103/physreve.102.062425
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发表时间：
2020-12-30
影响因子：
2.4
通讯作者：
Ghosh，Souparno
中科院分区：
文献类型：
--
作者：
Kara，Erdi;Rahman，Aminur;Ghosh，Souparno
近几十年来，计算机辅助技术在医学上已经变得普遍，然而，癌症药物通常只在活组织检查的体外细胞系上进行测试。我们推导出一个完整的三维模型的非均匀各向异性扩散的肿瘤区域耦合到一个二元人口模型，simulatesin vivoscenarios比传统的细胞系测试。使用扩散张量磁共振成像从诊断为多形性胶质母细胞瘤的患者获得扩散张量。然后，我们用有限元方法对完整模型进行数值模拟，并生成药物浓度热图、凋亡热点和剂量响应曲线。最后，对最佳注射位置和体积进行预测，这些预测以医生和肿瘤学家可以采用的形式呈现。
In recent decades computer-aided technologies have become prevalent in medicine, however, cancer drugs are often only tested onin vitrocell lines from biopsies. We derive a full three-dimensional model of inhomogeneous -anisotropic diffusion in a tumor region coupled to a binary population model, which simulatesin vivoscenarios faster than traditional cell-line tests. The diffusion tensors are acquired using diffusion tensor magnetic resonance imaging from a patient diagnosed with glioblastoma multiform. Then we numerically simulate the full model with finite element methods and produce drug concentration heat maps, apoptosis hotspots, and dose-response curves. Finally, predictions are made about optimal injection locations and volumes, which are presented in a form that can be employed by doctors and oncologists.