Wrong-way chloride transport: is it a treatable cause of some intractable seizures?
Wrong-way chloride transport: is it a treatable cause of some intractable seizures?
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DOI：
10.1111/j.1535-7511.2006.00119.x
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发表时间：
2006-07-01
影响因子：
3.6
通讯作者：
Staley, Kevin J
中科院分区：
文献类型：
--
作者：
Staley, Kevin J
尽管经过了几十年的研究和六种新的抗惊厥药物，但某些类型的癫痫发作现在和溴化物时代一样无法治疗。这些治疗抵抗性癫痫发作表明，一些关于抗惊厥机制的假设可能需要修改。本文将重点介绍癫痫学的一个基本假设，即神经递质GABA抑制神经元的活动，因此，增加GABA活性的药物应增加抑制作用，从而减少癫痫发作期间发生的异常神经元活动。
Despite decades of research and a half dozen new anticonvulsant agents, some types of seizures are as untreatable now as they were in the days of bromides. These treatment-resistant seizures suggest that some of the assumptions about anticonvulsant mechanisms may need revision. This review will focus on one of the bedrock assumptions of epileptology that the neurotransmitter GABA inhibits neuronal activity, and therefore, agents that increase GABA activity should increase inhibition and consequently decrease the abnormal neuronal activity that occurs during a seizure.