Preparation and characterization of macroporous chitosan-gelatin β-tricalcium phosphate composite scaffolds for bone tissue engineering
Preparation and characterization of macroporous chitosan-gelatin β-tricalcium phosphate composite scaffolds for bone tissue engineering
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DOI：
10.1002/jbm.a.10153
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发表时间：
2003-12-01
影响因子：
4.9
通讯作者：
Yao, KD
中科院分区：
文献类型：
--
作者：
Yin, YJ;Ye, F;Yao, KD
将β-磷酸三钙(β-TCP)与壳聚糖(CS)、明胶(Gel)以杂化聚合物网络(HPN)的形式与戊二醛共交联制得可生物降解的复合支架。采用冷冻干燥法制备了不同类型的支架。用傅立叶变换红外光谱、X射线衍射仪和扫描电子显微镜对材料进行了表征。大孔复合支架具有不同的孔结构。压缩性能得到改善，特别是压缩弹性系数在3.9~10.9 Mpa之间。在兔身上进行皮下生物相容性评价。12周后观察到轻微的炎症反应。结果表明，该支架可用于非负荷性骨再生。(C)2003年威利期刊公司。
A biodegradable composite scaffold was developed using beta-tricalcium phosphate (beta-TCP) with chitosan (CS) and gelatin (Gel) in the form of a hybrid polymer network (HPN) via co-crosslinking with glutaraldehyde. Various types of scaffolds were prepared by freezing and lyophilizing. These scaffolds were characterized by Fourier transform infrared, X-ray diffractometer, and scanning electron microscopy. The macroporous composite scaffolds exhibited different pore structures. Compressive properties were improved, especially compressive modulus from 3.9-10.9 MPa. Biocompatibility was evaluated subcutaneously on rabbits. A mild inflammatory response was observed over 12 weeks. The results suggest that the scaffolds can be utilized in nonloading bone regeneration. (C) 2003 Wiley Periodicals, Inc.