LOCAL RETINAL REGIONS CONTROL LOCAL EYE GROWTH AND MYOPIA
LOCAL RETINAL REGIONS CONTROL LOCAL EYE GROWTH AND MYOPIA
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DOI：
10.1126/science.3603011
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发表时间：
1987-07-03
期刊：
影响因子：
56.9
通讯作者：
FUGATEWENTZEK, LA
中科院分区：
文献类型：
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作者：
WALLMAN, J;GOTTLIEB, MD;FUGATEWENTZEK, LA
在小鸡中，视觉剥夺导致近视和眼睛的玻璃体腔扩大。当小鸡被饲养时，在眼睛上戴上白色半透明的遮光器，使鼻侧、颞侧或全部视网膜失去视觉，由此产生的近视（中位数= -15屈光度）仅限于视网膜的失去视觉的部分，而不管视网膜的哪一半失去视觉;非失去视觉的部分保持接近正视。相应地，玻璃体腔仅在视觉剥夺区域被拉长，导致眼睛具有不同的不对称形状，这取决于视网膜区域被剥夺。这些结果表明，眼睛生长的局部调节依赖于视力，并提出了一个假设，以解释人类近视的流行病学关联与大量的阅读。因为大多数非中央凹视网膜神经元有很大的感受野，所以它们不能分辨印刷页面上的单个字母;这可能导致它们在阅读时的活动比大多数其他形式的视觉刺激时要少。因此，阅读的贫乏刺激情况可能导致近视，其他类型的视觉形式剥夺也是如此。
In chicks, visual deprivation leads to myopia and enlargement of the vitreous chamber of the eye. When chicks were raised with white translucent occluders over their eye so that either the nasal half, the temporal half, or all the retina was visually deprived, the resulting myopia (median = -15 diopters) was limited to the deprived part of the retina, regardless of which half of the retina was visually deprived; the nondeprived part remained nearly emmetropic. Correspondingly, the vitreous chamber was elongated only in the region of the visual deprivation, resulting in eyes with different asymmetric shapes depending on which retinal region was deprived. These results argue for a local regulation of ocular growth that is dependent on vision and suggest a hypothesis to explain the epidemiological association of myopia in humans with large amounts of reading. Because most nonfoveal retinal neurons have large receptive fields, they cannot resolve the individual letters on the printed page; this may lead to their activity being less during reading than during most other forms of visual stimulation. Thus, the impoverished stimulus situation of reading may lead to myopia, as do other types of visual form deprivation.