The multiple function of long noncoding RNAs in osteosarcoma progression, drug resistance and prognosis
The multiple function of long noncoding RNAs in osteosarcoma progression, drug resistance and prognosis
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DOI：
10.1016/j.biopha.2020.110141
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发表时间：
2020-07-01
影响因子：
7.5
通讯作者：
Zhang, Ning
中科院分区：
文献类型：
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作者：
Xu, Shengjie;Gong, Yingchao;Zhang, Ning
骨肉瘤是一种常见于儿童和年轻人的骨肿瘤。lncRNA是一个长度超过200个核苷酸的非蛋白质编码转录物家族。lncRNA与肿瘤相关的病理功能包括增殖、迁移和化疗耐药，这些在骨肉瘤的研究中已被广泛认可。此外，令人信服的证据表明，lncRNA可以作为诊断指标，预后生物标志物和疾病治疗的靶点。本文就lncRNA如何调控肿瘤的发生、侵袭和耐药性作一综述。通过深入了解lncRNA与骨肉瘤的关系，我们希望尽快将研究结果转化为临床应用。
Osteosarcoma is a bone tumor prevalent in children and young adults. LncRNAs are a family of non-protein-coding transcripts longer than 200 nucleotides. The tumor-related pathological functions of lncRNAs include proliferation, migration, and chemotherapy resistance, all of which have been widely acknowledged in research on osteosarcoma. In addition, compelling evidence suggests that lncRNAs could serve as diagnostic indicators, prognostic biomarkers, and targets for disease treatment. In this review, we systematically summarize how lncRNAs regulate tumorigenesis, invasion and therapeutic resistance. By deepening our knowledge of the relationship between lncRNAs and osteosarcoma, we hope to translate research findings into clinical applications as soon as possible.