Distinct roles of basal forebrain cholinergic neurons in spatial and object recognition memory.
Distinct roles of basal forebrain cholinergic neurons in spatial and object recognition memory.
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DOI：
10.1038/srep13158
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发表时间：
2015-08-06
影响因子：
4.6
通讯作者：
Kobayashi K
中科院分区：
文献类型：
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作者：
Okada K;Nishizawa K;Kobayashi T;Sakata S;Kobayashi K
识别记忆需要处理各种类型的信息，如物体和位置。认知记忆障碍是遗忘症的一个显著特征，也是阿尔茨海默病（AD）的一个症状。基底前脑胆碱能神经元包括两大类，一类位于内侧隔（MS）/垂直Broca斜角带（vDB），另一类位于基底核（NBM）。这些细胞群在识别记忆中的作用一直存在争议，目前还不清楚它们是如何贡献的。我们使用遗传细胞靶向技术选择性地消除胆碱能细胞群，然后通过不同的行为任务测试空间和物体识别记忆。消除MS/vDB神经元损害空间，但不是对象识别记忆的参考和工作记忆任务，而NBM消除破坏工作记忆任务中的对象识别记忆。这些损伤可以通过乙酰胆碱酯酶抑制剂（AD的抗痴呆药物）治疗恢复。我们的研究结果强调，MS/vDB和NBM胆碱能神经元不仅涉及识别记忆，但也有不同类型的识别记忆中的重要作用。
Recognition memory requires processing of various types of information such as objects and locations. Impairment in recognition memory is a prominent feature of amnesia and a symptom of Alzheimer’s disease (AD). Basal forebrain cholinergic neurons contain two major groups, one localized in the medial septum (MS)/vertical diagonal band of Broca (vDB), and the other in the nucleus basalis magnocellularis (NBM). The roles of these cell groups in recognition memory have been debated, and it remains unclear how they contribute to it. We use a genetic cell targeting technique to selectively eliminate cholinergic cell groups and then test spatial and object recognition memory through different behavioural tasks. Eliminating MS/vDB neurons impairs spatial but not object recognition memory in the reference and working memory tasks, whereas NBM elimination undermines only object recognition memory in the working memory task. These impairments are restored by treatment with acetylcholinesterase inhibitors, anti-dementia drugs for AD. Our results highlight that MS/vDB and NBM cholinergic neurons are not only implicated in recognition memory but also have essential roles in different types of recognition memory.