Osteoclast differentiation by RANKL requires NF-κB-mediated downregulation of cyclin-dependent kinase 6 (Cdk6)
Osteoclast differentiation by RANKL requires NF-κB-mediated downregulation of cyclin-dependent kinase 6 (Cdk6)
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DOI：
10.1359/jbmr.2004.19.7.1128
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发表时间：
2004-07-01
影响因子：
6.2
通讯作者：
Kawaguchi, H
中科院分区：
文献类型：
--
作者：
Ogasawara, T;Katagiri, M;Kawaguchi, H
本研究探讨了RANKL诱导破骨细胞分化中细胞周期因子的参与。在G1期细胞周期因子中，Cdk 6作为NF-κ B信号的下游效应子，是决定破骨细胞分化速率的关键分子。
This study investigated the involvement of cell cycle factors in RANKL-induced osteoclast differentiation. Among the G1 cell cycle factors, Cdk6 was found to be a key molecule in determining the differentiation rate of osteoclasts as a downstream effector of the NF-kappaB signaling.