Plasma inflammatory biomarkers link to diffusion tensor imaging metrics in virally suppressed HIV-infected individuals
Plasma inflammatory biomarkers link to diffusion tensor imaging metrics in virally suppressed HIV-infected individuals
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DOI：
10.1097/qad.0000000000002404
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发表时间：
2020-02-01
期刊：
影响因子：
3.8
通讯作者：
Valcour, Victor
中科院分区：
文献类型：
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作者：
Chang, Kevin;Premeaux, Thomas A.;Valcour, Victor
目的：炎症可能有助于脑白色物质健康的人与艾滋病毒感染者谁报告认知症状，尽管坚持联合抗逆转录病毒治疗和病毒抑制。我们探讨了HIV感染人群中白色物质的扩散张量成像（DTI）指标、免疫激活的血浆生物标志物和认知功能之间的关系。设计图：对坚持联合抗逆转录病毒治疗、病毒抑制和自我报告认知症状的老年HIV感染者的回顾性研究方法：MRI，抽血，和标准化的神经心理学测试分数收集艾滋病毒感染者。定量DTI指标（各向异性分数、平均扩散率、径向扩散率、轴向扩散率）和血浆生物标志物（可溶性CD 163、可溶性CD 14、新蝶呤、IFN γ诱导蛋白10、单核细胞趋化蛋白1）。统计分析探讨了生物标志物水平或神经心理学测试分数与使用感兴趣区域分析和体素方法的DTI指标之间的关联。结果如下：共有43名参与者，中位（四分位数间距）年龄为64岁（62-66岁），CD 4（+）细胞计数为600（400-760细胞/μ l），均为病毒抑制（
Objective: Inflammation may contribute to brain white matter health in people living with HIV who report cognitive symptoms despite adherence to combination antiretroviral therapy and viral suppression. We explored relationships between diffusion tensor imaging (DTI) metrics of white matter, plasma biomarkers of immune activation, and cognitive function in the HIV-infected population. Design: Retrospective study of older adults living with HIV who are combination antiretroviral therapy adherent, virally suppressed, and self-report cognitive symptoms. Methods: MRI, blood draws, and standardized neuropsychological test scores were collected from HIV-infected individuals. DTI metrics (fractional anisotropy, mean diffusivity, radial diffusivity, axial diffusivity) and plasma biomarkers (soluble CD163, soluble CD14, neopterin, IFN gamma-induced protein 10, monocyte chemoattractant protein 1) were quantified. Statistical analysis explored associations between biomarker levels or neuropsychological test scores and DTI metrics using region of interest analyses and a voxelwise approach. Results: A total of 43 participants with median (interquartile range) age of 64 (62-66 years), CD4(+)cell count of 600 (400-760 cell/mu l) who were all virally suppressed (