Collective oscillations of coupled cell cycles.
Collective oscillations of coupled cell cycles.
复制标题
耦合细胞周期的集体振荡。
DOI：
10.1016/j.bpj.2021.06.029
复制
发表时间：
2021
影响因子：
3.4
通讯作者：
Shvartsman,StanislavY
中科院分区：
文献类型：
--
作者：
Shao,Binglun;Diegmiller,Rocky;Shvartsman,StanislavY
耦合振荡器网络的问题出现在多种情况下，通常导致网络动力学对网络结构的依赖性问题。以前的工作已经解决了这个问题，在果蝇胚胎发生中，稳定的细胞质桥将未来的卵母细胞与支持的护士细胞连接起来，为卵母细胞提供发育所需的分子和细胞器。为了增加其生物合成能力，保育细胞进入内复制程序，这是一种特殊形式的细胞周期，由生长和合成阶段的反复重复而形成，而没有有丝分裂。最近的研究表明，卵母细胞协调护士细胞内复制周期，基于逆行（卵母细胞到护士细胞）的细胞周期抑制剂的运输产生的护士细胞和本地化的卵母细胞。此外，联合动力学的内循环已被提出依赖于卵母细胞内的细胞间的连接性的护士细胞集群。我们使用的计算模型认为，这种连接的指南，但并不唯一地确定集体动态和确定几个振荡制度，这取决于时间尺度的细胞间运输。我们的研究结果提供了深入了解耦合细胞周期的集体动力学和激励未来的定量研究生殖细胞群中的细胞间通讯。
Problems with networks of coupled oscillators arise in multiple contexts, commonly leading to the question about the dependence of network dynamics on network structure. Previous work has addressed this question inDrosophilaoogenesis, in which stable cytoplasmic bridges connect the future oocyte to the supporting nurse cells that supply the oocyte with molecules and organelles needed for its development. To increase their biosynthetic capacity, nurse cells enter the endoreplication program, a special form of the cell cycle formed by the iterated repetition of growth and synthesis phases without mitosis. Recent studies have revealed that the oocyte orchestrates nurse cell endoreplication cycles, based on retrograde (oocyte to nurse cells) transport of a cell cycle inhibitor produced by the nurse cells and localized to the oocyte. Furthermore, the joint dynamics of endocycles has been proposed to depend on the intercellular connectivity within the oocyte-nurse cell cluster. We use a computational model to argue that this connectivity guides, but does not uniquely determine the collective dynamics and identify several oscillatory regimes, depending on the timescale of intercellular transport. Our results provide insights into collective dynamics of coupled cell cycles and motivate future quantitative studies of intercellular communication in the germline cell clusters.