Ocular Forward Light Scattering and Corneal Backward Light Scattering in Patients With Dry Eye
Ocular Forward Light Scattering and Corneal Backward Light Scattering in Patients With Dry Eye
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DOI：
10.1167/iovs.14-15125
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发表时间：
2014-10-01
影响因子：
4.4
通讯作者：
Nishida, Kohji
中科院分区：
文献类型：
--
作者：
Koh, Shizuka;Maeda, Naoyuki;Nishida, Kohji
目的.目的评价干眼患者眼前向光散射和角膜后向光散射的变化。干眼患者35例35眼，健康对照组20例20眼。根据中央6 mm角膜区（cSPK）是否存在浅表点状角膜病变，将35只干眼分为两组。用杂散光计定量眼部前向光散射。使用Scheimpflug成像系统，通过角膜密度测定程序评估前、中、后角膜部分的角膜后向光散射。两个干眼症组的眼内前向光散射均明显高于对照组（均P < 0.05）。干眼组与cSPK有显着更高的值在前和总角膜后向光散射比其他两个组。cSPK评分与前角膜后向光散射呈中度正相关（R = 0.60，P < 0.001）和全角膜后向光散射cSPK评分与眼前向光散射无相关性（R = 0.01，P = 0.932）。干眼症眼的前向光散射和前角膜的后向光散射均大于正常眼。干眼症中增加的角膜后向光散射至少部分地由覆盖光学区的cSPK引起。
PURPOSE. To evaluate ocular forward light scattering and corneal backward light scattering in patients with dry eye.METHODS. Thirty-five eyes in 35 patients with dry eye and 20 eyes of 20 healthy control subjects were enrolled. The 35 dry eyes were classified into two groups according to whether superficial punctate keratopathy in the central 6-mm corneal zone (cSPK) was present or not. Ocular forward light scattering was quantified with a straylight meter. Corneal backward light scattering from the anterior, middle, and posterior corneal parts was assessed with a corneal densitometry program using the Scheimpflug imaging system.RESULTS. Both dry eye groups had significantly higher intraocular forward light scattering than the control group (both P < 0.05). The dry eye group with cSPK had significantly higher values in anterior and total corneal backward light scattering than the other two groups. Moderate positive correlations were observed between the cSPK score and corneal backward light scattering from the anterior cornea (R = 0.60, P < 0.001) and corneal backward light scattering from the total cornea (R = 0.54, P < 0.001); however, no correlation was found between cSPK score and ocular forward light scattering (R = 0.01, P = 0.932).CONCLUSIONS. Ocular forward light scattering and corneal backward light scattering from the anterior cornea were greater in dry eyes than in normal eyes. Increased corneal backward light scattering in dry eye at least partially results from cSPK overlying the optical zone.