Potential anticancer heterometallic Fe-Au and Fe-Pd agents: initial mechanistic insights.
Potential anticancer heterometallic Fe-Au and Fe-Pd agents: initial mechanistic insights.
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DOI：
10.1021/jm4007615
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发表时间：
2013-07-25
影响因子：
7.3
通讯作者：
Contel M
中科院分区：
文献类型：
--
作者：
Lease N;Vasilevski V;Carreira M;de Almeida A;Sanaú M;Hirva P;Casini A;Contel M
A series of gold(III) and palladium(II) heterometallic complexes with new iminophosphorane ligands derived from ferrocenyl-phosphanes [{Cp-P(Ph2)=N-Ph}2Fe] (1), [{Cp-P(Ph2)=N-CH2-2-NC5H4}2Fe] (2) and [{Cp-P(Ph2)=N-CH2-2-NC5H4}Fe(Cp)] (3) have been synthesized and structurally characterized. Ligands 2 and 3 afford stable coordination complexes [AuCl2(3)]ClO4, [{AuCl2}2(2)](ClO4)2, [PdCl2(3)] and [{PdCl2}2(2)]. The complexes have been evaluated for their antripoliferative properties in human ovarian cancer cells sensitive and resistant to cisplatin (A2780S/R), in human breast cancer cells (MCF7) and in a non-tumorigenic human embryonic kidney cell line (HEK-293T). The highly cytotoxic trimetallic derivatives M2Fe (M = Au, Pd) are more cytotoxic to cancer cells than their corresponding monometallic fragments. Moreover, these complexes were significantly more cytotoxic than cisplatin in the resistant A2780R and the MCF7 cell lines. Studies of the interactions of the trimetallic compounds with DNA and the zinc-finger protein PARP-1 indicate that they exert anticancer effects in vitro based on different mechanisms of actions with respect to cisplatin.
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影响因子：
2.3
作者：
Auzias, Mathieu;Gueniat, Joeel;Dyson, Paul J.
通讯作者：
Dyson, Paul J.
影响因子：
2.8
作者：
Chellan, Prinessa;Land, Kirkwood M.;Smith, Gregory S.
通讯作者：
Smith, Gregory S.
影响因子：
3.3
作者：
Falvello, LR;García, MM;Urriolabeitia, EP
通讯作者：
Urriolabeitia, EP
影响因子：
2.8
作者：
Carreira M;Calvo-Sanjuán R;Sanaú M;Marzo I;Contel M
通讯作者：
Contel M
DOI：
10.1007/bf01114537
发表时间：
1990-04-01
期刊：
THEORETICA CHIMICA ACTA
影响因子：
--
作者：
ANDRAE, D;HAUSSERMANN, U;PREUSS, H
通讯作者：
PREUSS, H