A Mapping Between Structural and Functional Brain Networks
A Mapping Between Structural and Functional Brain Networks
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DOI：
10.1089/brain.2015.0408
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发表时间：
2016-05-01
影响因子：
3.4
通讯作者：
Van Mieghem, Piet
中科院分区：
文献类型：
--
作者：
Meier, Jil;Tewarie, Prejaas;Van Mieghem, Piet
大脑结构网络和功能网络之间的关系仍然存在高度争议。大多数先前的研究都使用单一的功能成像模式来分析这种关系。在这项工作中，我们使用多模态数据，来自功能MRI、脑磁图和弥散张量成像，并假设静息状态功能网络和结构网络的连接矩阵之间存在映射。我们使用群体平均和个人数据来研究这种映射。我们确实发现这种结构-功能映射具有非常高的拟合优度。我们的分析表明，在这两种模态的情况下，功能连接是由结构网络的直径形成的。在分析从功能到结构的逆映射时，在功能网络中行走的时间越长，对结构连接强度的影响似乎也较小。尽管在不同的功能模态中发现了相似的结构-功能映射的总体性质，但我们的结果表明，结构-功能关系依赖于模态。
The relationship between structural and functional brain networks is still highly debated. Most previous studies have used a single functional imaging modality to analyze this relationship. In this work, we use multimodal data, from functional MRI, magnetoencephalography, and diffusion tensor imaging, and assume that there exists a mapping between the connectivity matrices of the resting-state functional and structural networks. We investigate this mapping employing group averaged as well as individual data. We indeed find a significantly high goodness of fit level for this structure-function mapping. Our analysis suggests that a functional connection is shaped by all walks up to the diameter in the structural network in both modality cases. When analyzing the inverse mapping, from function to structure, longer walks in the functional network also seem to possess minor influence on the structural connection strengths. Even though similar overall properties for the structure-function mapping are found for different functional modalities, our results indicate that the structure-function relationship is modality dependent.