Heterogeneity of resting and hyperemic myocardial blood flow in healthy humans
Heterogeneity of resting and hyperemic myocardial blood flow in healthy humans
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DOI：
10.1016/s0008-6363(01)00202-4
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发表时间：
2001-04-01
影响因子：
10.8
通讯作者：
Camici, PG
中科院分区：
文献类型：
--
作者：
Chareonthaitawee, P;Kaufmann, PA;Camici, PG
目的：绝对心肌血流量（MBF）在大的正常人群中并没有很好的定义，并且在人类和动物中似乎是异质的。这些因素导致了静息心肌血流量与冬眠心肌定义的困难。因此，我们评估了大量正常人群的绝对基线和充血MBF。研究方法：在基线和腺苷或潘生丁诱导的充血期间，131名男性和38名女性，年龄21-86岁（平均46+/-12岁），通过正电子发射断层扫描用氧-15标记水定量MBF。使用心率-血压乘积（RPP）校正MBF的工作负荷。结果如下：未校正的基线MBF范围为0.590 - 2.050（平均值0.985+/-0.230）ml/min/g（变异系数=27%），校正的MBF范围为0.736 - 2.428（平均值1.330+/-0.316）ml/min/g（变异系数=24%）。下区MBF显著高于下区（P
Objective: Absolute myocardial blood flow (MBF) is not well-defined in large normal populations, and appears to be heterogeneous in both humans and animals. These factors contribute to the difficulties in defining resting MBF to hibernating myocardium. We therefore assessed absolute baseline and hyperemic MBF in a large population of normal humans. Methods: MBF was quantified by positron emission tomography with oxygen-15-labeled water at baseline and during hyperemia induced by either adenosine or dipyridamole in 131 men and 38 women, aged 21-86 (mean 46+/-12) years. MBF was corrected for workload using the rate-pressure product (RPP). Results: Uncorrected baseline MBF ranged from 0.590 to 2.050 (mean 0.985+/-0.230) ml/min/g (coefficient of variation=27%), and corrected MBF from 0.736 to 2.428 (mean 1.330+/-0.316) ml/min/g (coefficient of variation=24%). MBF in the inferior region was significantly (P