Dissecting miRNA signature in colorectal cancer progression and metastasis
Dissecting miRNA signature in colorectal cancer progression and metastasis
复制标题
解析结直肠癌进展和转移中的 miRNA 特征
DOI：
10.1016/j.canlet.2020.12.025
复制
发表时间：
2021-01-09
期刊：
影响因子：
9.7
通讯作者：
Cui, Ri
中科院分区：
文献类型：
--
作者：
Huang, Xiangjie;Zhu, Xinping;Cui, Ri
结直肠癌（CRC）是世界范围内第三大常见癌症和癌症相关死亡的主要原因。尽管最近在外科和分子靶向治疗方面取得了进展，提高了CRC的治疗效果，但CRC患者的5年生存率仍然令人沮丧地低。越来越多的证据表明microRNAs（miRNAs）在结直肠癌的发生、发展和转移中起着重要作用。失调的miRNA通过调节其靶基因与癌表型（例如增强的增殖和侵袭能力、逃避凋亡、细胞周期畸变和促进血管生成）密切相关。本文综述了肿瘤抑制和致癌miRNAs、循环miRNAs以及CRC中miRNAs失调的可能原因。此外，我们还讨论了miRNA在大肠癌耐药中的重要作用。
Colorectal cancer (CRC) is the third most common cancer and leading cause of cancer related deaths worldwide. Despite recent advancements in surgical and molecular targeted therapies that improved the therapeutic efficacy in CRC, the 5 years survival rate of CRC patients still remains frustratingly poor. Accumulated evidences indicate that microRNAs (miRNAs) play a crucial role in the progression and metastasis of CRC. Dysregulated miRNAs are closely associated with cancerous phenotypes (e.g. enhanced proliferative and invasive ability, evasion of apoptosis, cell cycle aberration, and promotion of angiogenesis) by regulating their target genes. In this review, we provide an updated overview of tumor suppressive and oncogenic miRNAs, circulatory miRNAs, and the possible causes of dysregulated miRNAs in CRC. In addition, we discuss the important functions of miRNAs in drug resistance of CRC.