Thalamic and brainstem contributions to large-scale plasticity of primate somatosensory cortex
Thalamic and brainstem contributions to large-scale plasticity of primate somatosensory cortex
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DOI：
10.1126/science.282.5391.1121
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发表时间：
1998-11-06
期刊：
影响因子：
56.9
通讯作者：
Pons, TP
中科院分区：
文献类型：
--
作者：
Jones, EG;Pons, TP
猕猴的上肢长期去神经后，躯体感觉皮层中的面部表征扩展了许多毫米，变成了手的沉默表征。对这一现象提出了各种脑干和皮层机制的解释，但丘脑的重组却被忽视了。在上肢去传入神经12 ~ 20年的猴中，发现脑干楔状核和丘脑腹后核发生了严重的跨神经元萎缩，丘脑的生理标测显示，面部和躯干的代表是相邻的白色，正常情况下，下面部的小代表已经扩大，大脑皮层脑干和丘脑核团的重组与缓慢的跨神经元萎缩有关，可能是一个渐进的过程，当与上行连接的分歧相结合时，它可能对皮层的代表性变化做出实质性贡献。
After long-term denervation of an upper limb in macaque monkeys, the representation of the face in somatosensory cortex expands over many millimeters into the silenced representation of the hand. Various brainstem and cortical mechanisms have been proposed to explain this phenomenon, Reorganization in the thalamus has been Largely ignored, In monkeys with deafferented upper Limbs for 12 to 20 years, it was found that the brainstem cuneate and the thalamic ventral posterior nuclei had undergone severe transneuronal atrophy, and physiological mapping in the thalamus revealed that the face and trunk representations were adjoined white the normally small representation of the lower face had expanded comparable to the expansion in cortex. Reorganization of brainstem and thalamic nuclei associated with slow transneuronal atrophy is likely to be a progressive process, When coupled with divergence of ascending connections, it is likely to make a substantial contribution to representational changes in cortex.