Bromine-Lithium Exchange on a gem-Dibromoalkene, Part 2: Comparative Performance of Flow Micromixers
Bromine-Lithium Exchange on a gem-Dibromoalkene, Part 2: Comparative Performance of Flow Micromixers
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宝石二溴烯烃上的溴-锂交换，第 2 部分：流动微混合器的性能比较
DOI：
10.1021/acs.oprd.0c00203
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发表时间：
2020
影响因子：
3.4
通讯作者：
Julien Legros
中科院分区：
文献类型：
--
作者：
Katia Perez;Baptiste Picard;Daniela Vuluga;Fabrice Burel;Rainier Hreiz;Laurent Falk;Jean-Marc Commenge;Aiichiro Nagaki;Jun-ichi Yoshida;Isabelle Chataigner;Jacques Maddaluno;Julien Legros
研究了混合器形状对锂-溴交换反应的立体选择性的影响。使用具有八个不同角度（135、120和105°（Y混合器）; 90°（T混合器）; 75、60、45和30°（W混合器））和两个内径（500和250 μm）的十六个被动混合器，其与具有500 μm内径的管式微流反应器相关联。具有较小内径的45° W形混合器在没有通常的低温条件（20 °C）的情况下在一定流速范围内对一溴化E产物给出了最佳选择性。以苯甲酰基甲酸甲酯为亲电试剂，以81 kg L ~（-1）h ~（-1）的时空产率得到相应的多官能化产物。
The influence of the mixer shape on the stereoselectivity was measured for lithium–bromine exchange on agem-dibromoalkene followed by proton trapping. Sixteen passive mixers with eight different angles (135, 120, and 105° (Y mixers); 90° (T mixer); 75, 60, 45, and 30° (W mixers)) and two internal diameters (500 and 250 μm) associated with a tubular microflow reactor having an internal diameter of 500 μm were used. The 45° W-shaped mixer with a smaller internal diameter gave the best selectivity for the monobrominatedEproduct over a range of flow rates without the usual cryogenic conditions (20 °C). With methyl benzoylformate as the electrophile, the corresponding polyfunctionalized product was obtained in a space-time yield of 81 kg L–1h–1.