Human polymorphonuclear leukocytes respond to waves of chemoattractant, like Dictyostelium
Human polymorphonuclear leukocytes respond to waves of chemoattractant, like Dictyostelium
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DOI：
10.1002/cm.10133
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发表时间：
2003-09-01
影响因子：
--
通讯作者：
Soll, DR
中科院分区：
文献类型：
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作者：
Geiger, J;Wessels, D;Soll, DR
已经假设，吸引人类多形核白细胞（PMN）在长距离的感染部位的天然趋化信号是在一个常设的空间梯度的化学引诱物的形式。我们质疑这一假设的理由，第一，站立的空间梯度可能不稳定，在很长一段时间内长距离，第二，在一个动物细胞趋化性系统中，其中自然的趋化信号已被描述在空间和时间，Dicytostesteriddiscoideum聚集，信号的形式是一个向外中继，非耗散波的吸引。在这里，它表明，中性粒细胞改变他们的行为，在每一个波的中性粒细胞化学引诱物的四个阶段，形成后的Dictyosteopathy波，以类似的方式Dictyosteopathy。这些结果表明，中性粒细胞有所有的机制，以响应一个自然波的引诱剂，提供支持的假设，吸引中性粒细胞在大距离的感染部位在人体内的自然信号也可能是波的形式。细胞动力。Cytoskeleton 56：27-44，2003. (C)2003 Wiley-Liss，Inc.
It has been assumed that the natural chemotactic signal that attracts human polymorphonuclear leukocytes (PMNs) over long distances to sites of infection is in the form of a standing spatial gradient of chemoattractant. We have questioned this assumption on the grounds, first, that standing spatial gradients may not be stable over long distances for long periods of time and, second, that in the one animal cell chemotaxis system in which the natural chemotactic signal has been described in space and time, aggregation of Dicytostelium discoideum, the signal is in the form of an outwardly relayed, nondissipating wave of attractant. Here, it is demonstrated that PMNs alter their behavior in each of the four phases of a wave of PMN chemoattractant, fashioned after the Dictyostelium wave, in a manner similar to Dictyostelium. These results demonstrate that PMNs have all of the machinery to respond to a natural wave of attractant, providing support to the hypothesis that the natural signal that attracts PMNs over large distances to sites of infection in the human body may also be in the form of a wave. Cell Motil. Cytoskeleton 56:27-44, 2003. (C) 2003 Wiley-Liss, Inc.